{"id":"d1984b02-a9e9-5114-9a96-91ef4fea5e58","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-portal-folic-acid-unmodified","predicate":"increases","statement":"Fifteen minutes after oral labeled folic acid, 80 ± 12% of portal dose-derived folate remained unchanged in five evaluable TIPSS subjects among six dosed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"38cc368f-063e-5379-95aa-b39e9bf74713","mechanism_event_label":"Much folic acid reached the liver unchanged.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"d9d84cc9-71ef-5307-8a88-ea849ee7325a","slug":"portal-unmetabolized-folic-acid","display_name":"Portal venous unmetabolized folic acid fraction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"38cc368f-063e-5379-95aa-b39e9bf74713","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-portal-folic-acid-unmodified-event","event_type":"observed_intervention","label":"Much folic acid reached the liver unchanged.","description":"Fifteen minutes after oral labeled folic acid, 80 ± 12% of portal dose-derived folate remained unchanged in five evaluable TIPSS subjects among six dosed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d9d84cc9-71ef-5307-8a88-ea849ee7325a","slug":"portal-unmetabolized-folic-acid","display_name":"Portal venous unmetabolized folic acid fraction","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Portal/peripheral isotope crossover in six TIPSS patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"500 nmol oral isotope-labeled folic acid, about 220 micrograms","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The sixth subject had no detectable labeled portal folate at 15 minutes; small liver-disease cohort and shunt-altered peripheral kinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Much folic acid reached the liver unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic portal blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c9264928-d188-5bb1-9349-df00755dc5b5","evidence_kind":"source_excerpt","locator":"Lines 387-397","start_line":387,"end_line":397,"excerpt":"### folate-portal-folic-acid-unmodified\nFifteen minutes after oral labeled folic acid, 80 ± 12% of portal dose-derived folate remained unchanged in five evaluable TIPSS subjects among six dosed.\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Much folic acid reached the liver unchanged.\norganism: Homo sapiens\ntissue_or_cell_type: Hepatic portal blood\nexperimental_model: Portal/peripheral isotope crossover in six TIPSS patients\nlimitations: The sixth subject had no detectable labeled portal folate at 15 minutes; small liver-disease cohort and shunt-altered peripheral kinetics.\nexposure: 500 nmol oral isotope-labeled folic acid, about 220 micrograms\n[patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","model_system":"Portal/peripheral isotope crossover in six TIPSS patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [patanwala2014] Folic acid handling by the human gut: implications for food fortification and supplementation (2014). https://pubmed.ncbi.nlm.nih.gov/24944062/ DOI: 10.3945/ajcn.113.080507","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}