Component
Porcine thyroglobulin iodination
Porcine thyroglobulin iodination
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Purified hog TPO catalyzed iodine incorporation into hog thyroglobulin in kinetic assays of protein iodination.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_span
- {"source_cache": "artifacts/iodine-synthesis-sources/6706940.json", "json_field": "abstractText", "text_sha256": "e7d184d64b66b0dc89f61c511688c79ffc9785b20233e7746ef4c97de351c78c", "text_characters": 1442, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."}
- experimental_model
- Purified hog thyroid peroxidase with hog thyroglobulin; steady-state and stopped-flow kinetics
- exposure
- Purified hog TPO; native TG with 1.0% iodine and further-iodinated TG with 1.2% iodine; reagent concentrations not stated in abstract.
- limitations
- Reaction measures TG iodination, not free iodotyrosine recycling. The proposed iodinium intermediate is a model, not imported as an established mechanism.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Sus scrofa
- plain_language
- TPO attaches iodine to tyrosine residues within the TG protein.
- primary_references
- [iodine-syn-tpo-iodination1984] Iodination and oxidation of thyroglobulin catalyzed by thyroid peroxidase. (1984). https://pubmed.ncbi.nlm.nih.gov/6706940/ DOI: 10.1016/s0021-9258(17)43667-2
- tissue_or_cell_type
- Purified thyroid enzyme and protein substrate
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 828–840
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified hog thyroid peroxidase with hog thyroglobulin; steady-state and stopped-flow kinetics · source_derived_draft · unverified_draft
### iodine-syn-tpo-protein-iodination Purified hog TPO catalyzed iodine incorporation into hog thyroglobulin in kinetic assays of protein iodination. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: TPO attaches iodine to tyrosine residues within the TG protein. organism: Sus scrofa tissue_or_cell_type: Purified thyroid enzyme and protein substrate experimental_model: Purified hog thyroid peroxidase with hog thyroglobulin; steady-state and stopped-flow kinetics limitations: Reaction measures TG iodination, not free iodotyrosine recycling. The proposed iodinium intermediate is a model, not imported as an established mechanism. exposure: Purified hog TPO; native TG with 1.0% iodine and further-iodinated TG with 1.2% iodine; reagent concentrations not stated in abstract. cross_nutrient: false evidence_span: {"source_cache": "artifacts/iodine-synthesis-sources/6706940.json", "json_field": "abstractText", "text_sha256": "e7d184d64b66b0dc89f61c511688c79ffc9785b20233e7746ef4c97de351c78c", "text_characters": 1442, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."} [iodine-syn-tpo-iodination1984] Iodination and oxidation of thyroglobulin catalyzed by thyroid peroxidase. (1984). https://pubmed.ncbi.nlm.nih.gov/6706940/ DOI: 10.1016/s0021-9258(17)43667-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.