Component
Polyphenon E green tea catechin mixture
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In a 30-person crossover study, fasting produced more than 3.5-fold higher free-EGCG peak concentrations than fed administration.
Experimental context and source evidence
- experimental_model
- Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group.
- limitations
- Mixture and high experimental doses; greater exposure is not a recommendation to take extracts fasting. Nausea was most frequent at 1200 mg fasting.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- Food changed how much free EGCG reached the blood.
- primary_references
- Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15958649/ · DOI 10.1158/1078-0432.ccr-04-2549
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 460–466
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group. · source_derived_draft · unverified_draft
## egcg-fasting Food changed how much free EGCG reached the blood. In a 30-person crossover study, fasting produced more than 3.5-fold higher free-EGCG peak concentrations than fed administration. Model: Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group. Limitations: Mixture and high experimental doses; greater exposure is not a recommendation to take extracts fasting. Nausea was most frequent at 1200 mg fasting. Evidence access: primary abstract. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15958649/ · DOI 10.1158/1078-0432.ccr-04-2549
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.