{"id":"a1418e66-4584-5269-8034-f6d1166b26f3","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-fasting","predicate":"has_food_dependent_exposure","statement":"In a 30-person crossover study, fasting produced more than 3.5-fold higher free-EGCG peak concentrations than fed administration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9deda524-b5ff-57d2-b4fc-a2c62994abe0","mechanism_event_label":"Food changed how much free EGCG reached the blood.","subject":{"id":"3aa5dca6-3c11-5c24-858d-95beabe08488","slug":"polyphenon-e","display_name":"Polyphenon E green tea catechin mixture","entity_type_key":"chemical_species"},"object":{"id":"f494c89c-9b18-5eb2-a1dd-aef0f82510a7","slug":"free-egcg-plasma-exposure","display_name":"Free EGCG plasma exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9deda524-b5ff-57d2-b4fc-a2c62994abe0","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-fasting-event","event_type":"observed_relationship","label":"Food changed how much free EGCG reached the blood.","description":"In a 30-person crossover study, fasting produced more than 3.5-fold higher free-EGCG peak concentrations than fed administration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3aa5dca6-3c11-5c24-858d-95beabe08488","slug":"polyphenon-e","display_name":"Polyphenon E green tea catechin mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f494c89c-9b18-5eb2-a1dd-aef0f82510a7","slug":"free-egcg-plasma-exposure","display_name":"Free EGCG plasma exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mixture and high experimental doses; greater exposure is not a recommendation to take extracts fasting. Nausea was most frequent at 1200 mg fasting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Food changed how much free EGCG reached the blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15958649/ · DOI 10.1158/1078-0432.ccr-04-2549","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3d674a2f-948e-5807-b043-fa95dc2c944f","evidence_kind":"source_excerpt","locator":"Lines 460-466","start_line":460,"end_line":466,"excerpt":"## egcg-fasting\nFood changed how much free EGCG reached the blood.\nIn a 30-person crossover study, fasting produced more than 3.5-fold higher free-EGCG peak concentrations than fed administration.\nModel: Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group.\nLimitations: Mixture and high experimental doses; greater exposure is not a recommendation to take extracts fasting. Nausea was most frequent at 1200 mg fasting.\nEvidence access: primary abstract.\nEffects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15958649/ · DOI 10.1158/1078-0432.ccr-04-2549","model_system":"Polyphenon E providing 400, 800 or 1200 mg EGCG; 10 subjects per dose group.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}