Component
Polarized epithelial basolateral membrane
Polarized epithelial basolateral membrane
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mouse ZIP5 localized to the basolateral membrane when expressed in polarized MDCK cells.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Polarized Madin-Darby canine kidney cells expressing mouse ZIP5
- exposure
- Polarized-cell localization assay.
- limitations
- Localization supports a directional hypothesis but does not itself measure net intestinal zinc excretion or demonstrate human renal zinc reabsorption.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Mouse protein in Canis lupus familiaris cells
- plain_language
- In polarized kidney-derived cells, ZIP5 sat on the side facing the tissue rather than the lumen.
- primary_references
- [zinc-trans-15322118] The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. (2004). https://pubmed.ncbi.nlm.nih.gov/15322118/ DOI: 10.1074/jbc.m408361200
- tissue_or_cell_type
- MDCK epithelial basolateral membrane
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 375–386
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Polarized Madin-Darby canine kidney cells expressing mouse ZIP5 · source_derived_draft · unverified_draft
### zinc-trans-zip5-basolateral Mouse ZIP5 localized to the basolateral membrane when expressed in polarized MDCK cells. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: In polarized kidney-derived cells, ZIP5 sat on the side facing the tissue rather than the lumen. organism: Mouse protein in Canis lupus familiaris cells tissue_or_cell_type: MDCK epithelial basolateral membrane experimental_model: Polarized Madin-Darby canine kidney cells expressing mouse ZIP5 limitations: Localization supports a directional hypothesis but does not itself measure net intestinal zinc excretion or demonstrate human renal zinc reabsorption. exposure: Polarized-cell localization assay. cross_nutrient: false [zinc-trans-15322118] The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. (2004). https://pubmed.ncbi.nlm.nih.gov/15322118/ DOI: 10.1074/jbc.m408361200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.