Component
PLOD2 dimer
Protein-bound site or substrate state, not free dietary L-lysine. Sequence and assay context limit the relationship.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
FKBP65 supports LH2/PLOD2 dimer formation in the tested collagen-producing cell systems.
Experimental context and source evidence
- experimental_model
- Human collagen-producing fibroblasts and expression constructs; predominantly LH2B dimerization/interaction assays.
- limitations
- This is an experimentally scoped assembly mechanism; free lysine supplementation was not tested.
- organism
- Human
- plain_language
- A helper protein helps assemble the collagen-modifying enzyme.
- primary_references
- [plod2-fkbp65-2016] Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2 (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC4932945/ DOI: 10.1073/pnas.1600074113
- tissue_or_cell_type
- Not specified as a whole tissue; see experimental model.
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 407–415
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human collagen-producing fibroblasts and expression constructs; predominantly LH2B dimerization/interaction assays. · source_derived_draft · unverified_draft
### fkbp65-plod2-dimer FKBP65 supports LH2/PLOD2 dimer formation in the tested collagen-producing cell systems. Plain language: A helper protein helps assemble the collagen-modifying enzyme. Condition category: normal organism: Human tissue_or_cell_type: Not specified as a whole tissue; see experimental model. experimental_model: Human collagen-producing fibroblasts and expression constructs; predominantly LH2B dimerization/interaction assays. limitations: This is an experimentally scoped assembly mechanism; free lysine supplementation was not tested. [plod2-fkbp65-2016] Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2 (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC4932945/ DOI: 10.1073/pnas.1600074113
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.