Component
Plasma total glutathione concentration
Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Plasma total glutathione rose 38% during restriction; plasma cysteine, homocysteine and CRP did not significantly change.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- B6-dependent sulfur metabolism connects to glutathione, with blood and cellular pools distinguished.
- experimental_model
- Nine healthy adults (five women, four men; ages 20–30), controlled restriction with fasting stable-isotope measurements.
- exposure
- Four weeks below 0.5 mg/day dietary B6; overnight-fasted tracer protocol.
- limitations
- Plasma total glutathione is not intracellular reduced GSH, tissue antioxidant capacity or synthesis rate.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- This experiment did not find a universal glutathione collapse.
- primary_references
- [b6-davis2006] Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women (2006). https://pubmed.ncbi.nlm.nih.gov/16424114/ DOI: 10.1093/jn/136.2.373
- tissue_or_cell_type
- Human blood and whole-body measurements
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1321–1332
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nine healthy adults (five women, four men; ages 20–30), controlled restriction with fasting stable-isotope measurements. · source_derived_draft · unverified_draft
### b6-fasting-total-glutathione Plasma total glutathione rose 38% during restriction; plasma cysteine, homocysteine and CRP did not significantly change. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This experiment did not find a universal glutathione collapse. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Nine healthy adults (five women, four men; ages 20–30), controlled restriction with fasting stable-isotope measurements. limitations: Plasma total glutathione is not intracellular reduced GSH, tissue antioxidant capacity or synthesis rate. exposure: Four weeks below 0.5 mg/day dietary B6; overnight-fasted tracer protocol. cross_nutrient: B6-dependent sulfur metabolism connects to glutathione, with blood and cellular pools distinguished. [b6-davis2006] Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women (2006). https://pubmed.ncbi.nlm.nih.gov/16424114/ DOI: 10.1093/jn/136.2.373
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.