{"id":"fe9c621b-df30-5f72-96b2-ffb36ad4e3ea","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-fasting-total-glutathione","predicate":"restriction_increased_plasma_total_glutathione","statement":"Plasma total glutathione rose 38% during restriction; plasma cysteine, homocysteine and CRP did not significantly change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"baeb3248-4881-591a-8757-06b9b8d9d588","mechanism_event_label":"This experiment did not find a universal glutathione collapse.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"f9d8fdcd-162d-5e80-81a2-80149c515104","slug":"plasma-total-glutathione-concentration","display_name":"Plasma total glutathione concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"baeb3248-4881-591a-8757-06b9b8d9d588","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-fasting-total-glutathione-event","event_type":"observed_intervention","label":"This experiment did not find a universal glutathione collapse.","description":"Plasma total glutathione rose 38% during restriction; 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ages 20–30), controlled restriction with fasting stable-isotope measurements.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-davis2006] Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women (2006). https://pubmed.ncbi.nlm.nih.gov/16424114/ DOI: 10.1093/jn/136.2.373","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}