Component
Plasma thrombomodulin concentration
Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At 168 hours, the prespecified thrombomodulin comparison was nonsignificant (P=0.70).
Experimental context and source evidence
- experimental_model
- CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).
- exposure
- IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo.
- limitations
- The circulating marker is distinct from directly measuring endothelial repair.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Homo sapiens
- plain_language
- This vessel-injury marker did not show the proposed benefit.
- primary_references
- [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825
- tissue_or_cell_type
- Human blood or whole-person endpoints
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1743–1753
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). · source_derived_draft · unverified_draft
### c-citris-thrombomodulin-null At 168 hours, the prespecified thrombomodulin comparison was nonsignificant (P=0.70). Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: This vessel-injury marker did not show the proposed benefit. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo). limitations: The circulating marker is distinct from directly measuring endothelial repair. exposure: IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo. [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.