{"id":"0f000651-c47c-5313-99f1-4fd9a8d96b55","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-citris-thrombomodulin-null","predicate":"did_not_significantly_change_primary_thrombomodulin_marker","statement":"At 168 hours, the prespecified thrombomodulin comparison was nonsignificant (P=0.70).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e0e914d2-9a52-50b6-9f98-43d820c1bcb8","mechanism_event_label":"This vessel-injury marker did not show the proposed benefit.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"e73c9fb3-0658-55c7-9f10-48932580668c","slug":"plasma-thrombomodulin-concentration","display_name":"Plasma thrombomodulin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e0e914d2-9a52-50b6-9f98-43d820c1bcb8","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-citris-thrombomodulin-null-event","event_type":"observed_intervention","label":"This vessel-injury marker did not show the proposed benefit.","description":"At 168 hours, the prespecified thrombomodulin comparison was nonsignificant (P=0.70).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e73c9fb3-0658-55c7-9f10-48932580668c","slug":"plasma-thrombomodulin-concentration","display_name":"Plasma thrombomodulin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The circulating marker is distinct from directly measuring endothelial repair.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This vessel-injury marker did not show the proposed benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"37a7effd-c1d5-54e4-bc35-1c4f748618e2","evidence_kind":"source_excerpt","locator":"Lines 1743-1753","start_line":1743,"end_line":1753,"excerpt":"### c-citris-thrombomodulin-null\nAt 168 hours, the prespecified thrombomodulin comparison was nonsignificant (P=0.70).\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This vessel-injury marker did not show the proposed benefit.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).\nlimitations: The circulating marker is distinct from directly measuring endothelial repair.\nexposure: IV vitamin C 50 mg/kg in 5% dextrose every six hours for 96 hours versus dextrose placebo.\n[c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825","model_system":"CITRIS-ALI: double-blind multicenter randomized trial; 170 initially randomized, three subsequently excluded without receiving C, 167 in the reported analysis (84 C, 83 placebo).","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-fowler2019] Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial (2019). https://pubmed.ncbi.nlm.nih.gov/31573637/ DOI: 10.1001/jama.2019.11825","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}