Component
Plasma strong-ion difference
Plasma strong-ion difference. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The fall in strong-ion difference was greater after saline than Plasma-Lyte.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/22580944.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814", "start_char": 0, "end_char": 1757, "text_sha256": "7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814"}
- experimental_model
- Randomized blinded crossover
- exposure
- 2 L saline or Plasma-Lyte 148 over one hour
- limitations
- IV fluid formulations differ in several components; short-term perfusion is not kidney failure or dietary salt exposure.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Twelve healthy adult men
- plain_language
- The balance of strong ions changed alongside the chloride rise.
- primary_references
- [chloride-p22580944] A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. (2012). https://pubmed.ncbi.nlm.nih.gov/22580944/ DOI: 10.1097/sla.0b013e318256be72
- tissue_or_cell_type
- Renal MRI and blood chemistry
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 978–989
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized blinded crossover · source_derived_draft · unverified_draft
### chloride-saline-sid The fall in strong-ion difference was greater after saline than Plasma-Lyte. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The balance of strong ions changed alongside the chloride rise. organism: Twelve healthy adult men tissue_or_cell_type: Renal MRI and blood chemistry experimental_model: Randomized blinded crossover limitations: IV fluid formulations differ in several components; short-term perfusion is not kidney failure or dietary salt exposure. exposure: 2 L saline or Plasma-Lyte 148 over one hour evidence_span: {"source_cache": "artifacts/chloride-research/22580944.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814", "start_char": 0, "end_char": 1757, "text_sha256": "7d2fb56addfe8ab376d6b086ad5d0da5220a0f6ceaa5733612d927ad2edb1814"} [chloride-p22580944] A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte® 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. (2012). https://pubmed.ncbi.nlm.nih.gov/22580944/ DOI: 10.1097/sla.0b013e318256be72
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.