Component
Plasma glutathione concentration, assay pool unspecified
Plasma glutathione concentration, assay pool unspecified. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Plasma glutathione did not change during the pilot’s three-hour sampling period.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/22609537.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bfd228f5a8102a99fecaf7c6de8d1cb910afacd695cb3947c60987f54da431fa", "start_char": 0, "end_char": 1645, "text_sha256": "bfd228f5a8102a99fecaf7c6de8d1cb910afacd695cb3947c60987f54da431fa"}
- experimental_model
- Small crossover pharmacokinetic pilot in younger and older adults
- exposure
- 500 mg R-lipoic acid versus 500 mg racemic lipoic acid
- limitations
- The indexed abstract does not specify reduced versus total glutathione assay pool; retain that uncertainty. A three-hour blood measurement is not a test of all intracellular pools.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Human
- plain_language
- An acute blood measurement did not reproduce every cell-culture glutathione result.
- primary_references
- [ala-p22609537] Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. (2012). https://pubmed.ncbi.nlm.nih.gov/22609537/ DOI: 10.1016/j.phrs.2012.05.002
- tissue_or_cell_type
- Plasma
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 676–687
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Small crossover pharmacokinetic pilot in younger and older adults · source_derived_draft · unverified_draft
### ala-acute-plasma-gsh-null Plasma glutathione did not change during the pilot’s three-hour sampling period. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: An acute blood measurement did not reproduce every cell-culture glutathione result. organism: Human tissue_or_cell_type: Plasma experimental_model: Small crossover pharmacokinetic pilot in younger and older adults limitations: The indexed abstract does not specify reduced versus total glutathione assay pool; retain that uncertainty. A three-hour blood measurement is not a test of all intracellular pools. exposure: 500 mg R-lipoic acid versus 500 mg racemic lipoic acid evidence_span: {"source_cache": "artifacts/ala-research/22609537.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bfd228f5a8102a99fecaf7c6de8d1cb910afacd695cb3947c60987f54da431fa", "start_char": 0, "end_char": 1645, "text_sha256": "bfd228f5a8102a99fecaf7c6de8d1cb910afacd695cb3947c60987f54da431fa"} [ala-p22609537] Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. (2012). https://pubmed.ncbi.nlm.nih.gov/22609537/ DOI: 10.1016/j.phrs.2012.05.002
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.