Component
Plasma cholesterol concentration
Plasma cholesterol concentration. Experimental scope belongs to each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Plasma cholesterol fell during baseline as well as depletion and did not respond during the ten-day manganese repletion period.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Manganese handling and the measured downstream function.
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/friedman1987.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6", "start_char": 0, "end_char": 1186, "text_sha256": "ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6", "text_characters": 1186}
- experimental_model
- Controlled depletion and repletion in seven men aged 19–22
- exposure
- Three weeks at 2.59 mg Mn/day, then 39 days at 0.11 mg/day; repletion at 1.53 and 2.55 mg/day for five days each.
- limitations
- Small sequential purified-diet study without a parallel control. Findings are not diagnostic criteria; the paper’s factorial requirement estimates are not current recommended intakes.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- The cholesterol change was not a clean manganese-specific response.
- primary_references
- [mn-clin-friedman1987] Manganese balance and clinical observations in young men fed a manganese-deficient diet. (1987). https://pubmed.ncbi.nlm.nih.gov/3819860/ DOI: 10.1093/jn/117.1.133
- tissue_or_cell_type
- Skin and plasma
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 964–976
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled depletion and repletion in seven men aged 19–22 · source_derived_draft · unverified_draft
### mn-clin-depletion-cholesterol Plasma cholesterol fell during baseline as well as depletion and did not respond during the ten-day manganese repletion period. Condition category: nutrient_deficiency nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cholesterol change was not a clean manganese-specific response. organism: Homo sapiens tissue_or_cell_type: Skin and plasma experimental_model: Controlled depletion and repletion in seven men aged 19–22 limitations: Small sequential purified-diet study without a parallel control. Findings are not diagnostic criteria; the paper’s factorial requirement estimates are not current recommended intakes. exposure: Three weeks at 2.59 mg Mn/day, then 39 days at 0.11 mg/day; repletion at 1.53 and 2.55 mg/day for five days each. cross_nutrient: Manganese handling and the measured downstream function. evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/friedman1987.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6", "start_char": 0, "end_char": 1186, "text_sha256": "ddc0b39d872786b905ca06d9b2470ebdf926ef42822e346f6bf003a180be4ba6", "text_characters": 1186} [mn-clin-friedman1987] Manganese balance and clinical observations in young men fed a manganese-deficient diet. (1987). https://pubmed.ncbi.nlm.nih.gov/3819860/ DOI: 10.1093/jn/117.1.133
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.