Component
PEMT rs12325817 C allele in the 2006 depletion study
PEMT rs12325817 C allele in the 2006 depletion study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Among women, 18 of 23 PEMT rs12325817 C-allele carriers developed organ dysfunction during depletion; reported odds ratio 25, p=0.002.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/choline-research/16816108.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1", "start_char": 0, "end_char": 1424, "text_sha256": "555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1"}
- experimental_model
- Genotype association within the controlled depletion cohort
- exposure
- Common PEMT/CHDH/BHMT variants during low-choline feeding
- limitations
- Small candidate-gene study; does not support deterministic recommendations from one SNP. Shares participants with related depletion publications.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- This variant marked higher susceptibility in the small study.
- primary_references
- [choline-p16816108] Common genetic polymorphisms affect the human requirement for the nutrient choline. (2006). https://pubmed.ncbi.nlm.nih.gov/16816108/ DOI: 10.1096/fj.06-5734com
- tissue_or_cell_type
- 57 participants; liver and muscle endpoints
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1036–1047
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genotype association within the controlled depletion cohort · source_derived_draft · unverified_draft
### choline-pemt-snp-risk Among women, 18 of 23 PEMT rs12325817 C-allele carriers developed organ dysfunction during depletion; reported odds ratio 25, p=0.002. Condition category: nutrient_deficiency nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: This variant marked higher susceptibility in the small study. organism: Human tissue_or_cell_type: 57 participants; liver and muscle endpoints experimental_model: Genotype association within the controlled depletion cohort limitations: Small candidate-gene study; does not support deterministic recommendations from one SNP. Shares participants with related depletion publications. exposure: Common PEMT/CHDH/BHMT variants during low-choline feeding evidence_span: {"source_cache": "artifacts/choline-research/16816108.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1", "start_char": 0, "end_char": 1424, "text_sha256": "555f2ace5850ed1fce7061ce91c5133cac7d92c29fdab192b0aa595f9dd390b1"} [choline-p16816108] Common genetic polymorphisms affect the human requirement for the nutrient choline. (2006). https://pubmed.ncbi.nlm.nih.gov/16816108/ DOI: 10.1096/fj.06-5734com
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.