Component
Two eggs plus d9-phosphatidylcholine challenge in the 2013 study
Two eggs plus d9-phosphatidylcholine challenge in the 2013 study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The challenge produced time-dependent increases in TMAO and its d9-labeled isotopologue.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/23614584.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de33f54f0fce1c470cc96c18163574d26fc5c56802e60771c75fdacc5804e0a", "start_char": 0, "end_char": 2119, "text_sha256": "9de33f54f0fce1c470cc96c18163574d26fc5c56802e60771c75fdacc5804e0a"}
- experimental_model
- Human isotope challenge with antibiotics plus a separate observational cohort
- exposure
- Two eggs plus d9-PC before/after antibiotics; three-year event follow-up
- limitations
- The challenge establishes microbiota involvement; the outcome cohort establishes association, not that avoiding choline or eggs prevents events.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- A label on dietary PC appeared in the downstream microbial-host product.
- primary_references
- [choline-p23614584] Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. (2013). https://pubmed.ncbi.nlm.nih.gov/23614584/ DOI: 10.1056/nejmoa1109400
- tissue_or_cell_type
- Healthy challenge participants; 4007 angiography patients in the outcome cohort
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1140–1151
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human isotope challenge with antibiotics plus a separate observational cohort · source_derived_draft · unverified_draft
### choline-pc-tmao-tracing The challenge produced time-dependent increases in TMAO and its d9-labeled isotopologue. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A label on dietary PC appeared in the downstream microbial-host product. organism: Human tissue_or_cell_type: Healthy challenge participants; 4007 angiography patients in the outcome cohort experimental_model: Human isotope challenge with antibiotics plus a separate observational cohort limitations: The challenge establishes microbiota involvement; the outcome cohort establishes association, not that avoiding choline or eggs prevents events. exposure: Two eggs plus d9-PC before/after antibiotics; three-year event follow-up evidence_span: {"source_cache": "artifacts/choline-research/23614584.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de33f54f0fce1c470cc96c18163574d26fc5c56802e60771c75fdacc5804e0a", "start_char": 0, "end_char": 2119, "text_sha256": "9de33f54f0fce1c470cc96c18163574d26fc5c56802e60771c75fdacc5804e0a"} [choline-p23614584] Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. (2013). https://pubmed.ncbi.nlm.nih.gov/23614584/ DOI: 10.1056/nejmoa1109400
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.