Component
PDE2/PDE5 activity in Park 2012
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Resveratrol did not inhibit tested PDE2 or PDE5 activity in the same recombinant panel.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Cell-free comparison.
- limitations
- Not a general inhibitor of every cyclic-nucleotide phosphodiesterase.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- The PDE effect is selective within the tested panel.
- primary_references
- Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 230–236
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cell-free comparison. · source_derived_draft · unverified_draft
## resveratrol-pde-selectivity The PDE effect is selective within the tested panel. Resveratrol did not inhibit tested PDE2 or PDE5 activity in the same recombinant panel. Model: Cell-free comparison. Limitations: Not a general inhibitor of every cyclic-nucleotide phosphodiesterase. Evidence access: Primary full text Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.