{"id":"8d65ca24-8597-513f-b8bb-479abe811a60","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-pde-selectivity","predicate":"did_not_inhibit","statement":"Resveratrol did not inhibit tested PDE2 or PDE5 activity in the same recombinant panel.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e6a5b53b-c9ab-5765-b2ec-1c1c5effbe4b","mechanism_event_label":"The PDE effect is selective within the tested panel.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"b17bb924-f2b7-5b2d-8961-8601a2f540f1","slug":"park-pde2-pde5-activity","display_name":"PDE2/PDE5 activity in Park 2012","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e6a5b53b-c9ab-5765-b2ec-1c1c5effbe4b","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-pde-selectivity-event","event_type":"observed_relationship","label":"The PDE effect is selective within the tested panel.","description":"Resveratrol did not inhibit tested PDE2 or PDE5 activity in the same recombinant panel.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b17bb924-f2b7-5b2d-8961-8601a2f540f1","slug":"park-pde2-pde5-activity","display_name":"PDE2/PDE5 activity in Park 2012","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a general inhibitor of every cyclic-nucleotide phosphodiesterase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The PDE effect is selective within the tested panel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0db1d253-02ec-5e3c-a970-9d357901fde5","evidence_kind":"source_excerpt","locator":"Lines 230-236","start_line":230,"end_line":236,"excerpt":"## resveratrol-pde-selectivity\nThe PDE effect is selective within the tested panel.\nResveratrol did not inhibit tested PDE2 or PDE5 activity in the same recombinant panel.\nModel: Cell-free comparison.\nLimitations: Not a general inhibitor of every cyclic-nucleotide phosphodiesterase.\nEvidence access: Primary full text\nResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017","model_system":"Cell-free comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}