Component
Clinical symptoms during pantothenate depletion
Clinical symptoms during pantothenate depletion. Experimental scope belongs to the associated record.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In the four-man normal-diet experiment, the intermediate-antagonist subject developed gastrointestinal and neurological symptoms, while the highest-exposure subject had mainly a transient tremor; the control and lowest-exposure subject remained relatively well.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary PDF pp.1421–1425, especially Results and Summary.
- experimental_model
- Historical four-man controlled antagonist experiment on a balanced 3200 kcal diet
- exposure
- One control; three men received escalating antagonist regimens, up to 2–4 g/day in the highest-exposure subject; pantothenic acid 4 g/day was later given after antagonist withdrawal.
- limitations
- Pharmacological antagonist exposure with an otherwise normal diet, not dietary B5 deprivation. Very small sample and concurrent antagonist withdrawal prevent isolating a pure vitamin-rescue effect. The interindividual pattern is not a monotonic dose-response or a direct assay of a specific PANK isoform.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Homo sapiens
- plain_language
- Blocking vitamin use experimentally produced variable illness despite a normal diet.
- primary_references
- [b5-clin-hodges1959] Human pantothenic acid deficiency produced by omega-methyl pantothenic acid. (1959). https://pubmed.ncbi.nlm.nih.gov/13673099/ DOI: 10.1172/jci103918
- tissue_or_cell_type
- Whole-person clinical symptoms and functional tests
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1201–1213
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical four-man controlled antagonist experiment on a balanced 3200 kcal diet · source_derived_draft · unverified_draft
### b5-clin-antagonist-variable-symptoms In the four-man normal-diet experiment, the intermediate-antagonist subject developed gastrointestinal and neurological symptoms, while the highest-exposure subject had mainly a transient tremor; the control and lowest-exposure subject remained relatively well. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking vitamin use experimentally produced variable illness despite a normal diet. organism: Homo sapiens tissue_or_cell_type: Whole-person clinical symptoms and functional tests experimental_model: Historical four-man controlled antagonist experiment on a balanced 3200 kcal diet limitations: Pharmacological antagonist exposure with an otherwise normal diet, not dietary B5 deprivation. Very small sample and concurrent antagonist withdrawal prevent isolating a pure vitamin-rescue effect. The interindividual pattern is not a monotonic dose-response or a direct assay of a specific PANK isoform. exposure: One control; three men received escalating antagonist regimens, up to 2–4 g/day in the highest-exposure subject; pantothenic acid 4 g/day was later given after antagonist withdrawal. cross_nutrient: false evidence_location: Primary PDF pp.1421–1425, especially Results and Summary. [b5-clin-hodges1959] Human pantothenic acid deficiency produced by omega-methyl pantothenic acid. (1959). https://pubmed.ncbi.nlm.nih.gov/13673099/ DOI: 10.1172/jci103918
Complete structured claim and evidenceIn the 1958 six-man study, the two men on the B5-devoid diet developed fatigue, behavioral and gastrointestinal complaints and impaired coordination after the antagonist-treated pair; the supplemented controls remained well.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary PDF pp.1643–1654; design, results and discussion.
- experimental_model
- Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls
- exposure
- Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.
- limitations
- Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Homo sapiens
- plain_language
- Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given.
- primary_references
- [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756
- tissue_or_cell_type
- Whole-person symptoms, serum and urine
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1145–1157
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls · source_derived_draft · unverified_draft
### b5-clin-diet-symptoms In the 1958 six-man study, the two men on the B5-devoid diet developed fatigue, behavioral and gastrointestinal complaints and impaired coordination after the antagonist-treated pair; the supplemented controls remained well. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given. organism: Homo sapiens tissue_or_cell_type: Whole-person symptoms, serum and urine experimental_model: Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls limitations: Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold. exposure: Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium. cross_nutrient: false evidence_location: Primary PDF pp.1643–1654; design, results and discussion. [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.