{"id":"a27821e0-9664-5637-9bbe-5892e3fe38b4","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-diet-symptoms","predicate":"deprivation-accompanied","statement":"In the 1958 six-man study, the two men on the B5-devoid diet developed fatigue, behavioral and gastrointestinal complaints and impaired coordination after the antagonist-treated pair; the supplemented controls remained well.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"05dbbe45-df28-54b3-a7d3-70058606fcb6","mechanism_event_label":"Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"5d51faa4-fc18-506d-a2a3-7cc50b00fa2a","slug":"pantothenate-depletion-clinical-symptoms","display_name":"Clinical symptoms during pantothenate depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"05dbbe45-df28-54b3-a7d3-70058606fcb6","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-diet-symptoms-event","event_type":"observed_intervention","label":"Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given.","description":"In the 1958 six-man study, the two men on the B5-devoid diet developed fatigue, behavioral and gastrointestinal complaints and impaired coordination after the antagonist-treated pair; the supplemented controls remained well.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e3aec528-bdfb-54a8-9b32-53fd3f1b9ff9","slug":"omega-methyl-pantothenate","display_name":"Omega-methyl pantothenic acid","entity_type_key":"small_molecule"},"role":"additional exposure in a separate pair","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d51faa4-fc18-506d-a2a3-7cc50b00fa2a","slug":"pantothenate-depletion-clinical-symptoms","display_name":"Clinical symptoms during pantothenate depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary PDF pp.1643–1654; design, results and discussion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-person symptoms, serum and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"69721234-927d-533f-9fef-4dd982d303bf","evidence_kind":"source_excerpt","locator":"Lines 1145-1157","start_line":1145,"end_line":1157,"excerpt":"### b5-clin-diet-symptoms\nIn the 1958 six-man study, the two men on the B5-devoid diet developed fatigue, behavioral and gastrointestinal complaints and impaired coordination after the antagonist-treated pair; the supplemented controls remained well.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Prolonged dietary depletion produced symptoms in this small controlled study, with earlier changes when an antagonist was also given.\norganism: Homo sapiens\ntissue_or_cell_type: Whole-person symptoms, serum and urine\nexperimental_model: Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls\nlimitations: Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold.\nexposure: Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.\ncross_nutrient: false\nevidence_location: Primary PDF pp.1643–1654; design, results and discussion.\n[b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","model_system":"Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}