Component
Pancreatic zinc retention
Pancreatic zinc retention
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Pancreatic acinar-cell Zip5 deletion impaired retention of administered 67Zn despite no detected impairment of rapid pancreatic 67Zn accumulation.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Acinar-cell-specific knockout and 67Zn tracer kinetics
- exposure
- Tracer zinc uptake and retention compared between acinar knockouts and controls.
- limitations
- The negative acute-uptake result is retained; retention differences do not identify every influx or efflux pathway.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Mus musculus
- plain_language
- Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here.
- primary_references
- [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149
- tissue_or_cell_type
- Pancreatic acinar cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 401–412
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Acinar-cell-specific knockout and 67Zn tracer kinetics · source_derived_draft · unverified_draft
### zinc-trans-pancreas-zip5-retention Pancreatic acinar-cell Zip5 deletion impaired retention of administered 67Zn despite no detected impairment of rapid pancreatic 67Zn accumulation. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here. organism: Mus musculus tissue_or_cell_type: Pancreatic acinar cells experimental_model: Acinar-cell-specific knockout and 67Zn tracer kinetics limitations: The negative acute-uptake result is retained; retention differences do not identify every influx or efflux pathway. exposure: Tracer zinc uptake and retention compared between acinar knockouts and controls. cross_nutrient: false [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.