{"id":"236f353f-146f-5fb9-82f7-101b2a119f7c","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-pancreas-zip5-retention","predicate":"decreases","statement":"Pancreatic acinar-cell Zip5 deletion impaired retention of administered 67Zn despite no detected impairment of rapid pancreatic 67Zn accumulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f39b7270-e293-500a-82ff-c8ee419f4bd7","mechanism_event_label":"Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here.","subject":{"id":"6bff01dd-e99a-51b8-a4be-68d641532a23","slug":"mouse-acinar-slc39a5-knockout","display_name":"Mouse pancreatic acinar Slc39a5 knockout genotype","entity_type_key":"gene"},"object":{"id":"3c5fbcb1-0b33-5225-bd57-8666fcf2e80d","slug":"pancreatic-zinc-retention","display_name":"Pancreatic zinc retention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f39b7270-e293-500a-82ff-c8ee419f4bd7","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-pancreas-zip5-retention-event","event_type":"biochemical_relationship","label":"Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here.","description":"Pancreatic acinar-cell Zip5 deletion impaired retention of administered 67Zn despite no detected impairment of rapid pancreatic 67Zn accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d71153b-6474-5bc7-89ff-666b940683da","slug":"mouse-slc39a5","display_name":"Mouse ZIP5 (Slc39a5)","entity_type_key":"protein"},"role":"deleted_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"traced_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6bff01dd-e99a-51b8-a4be-68d641532a23","slug":"mouse-acinar-slc39a5-knockout","display_name":"Mouse pancreatic acinar Slc39a5 knockout genotype","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3c5fbcb1-0b33-5225-bd57-8666fcf2e80d","slug":"pancreatic-zinc-retention","display_name":"Pancreatic zinc retention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acinar-cell-specific knockout and 67Zn tracer kinetics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tracer zinc uptake and retention compared between acinar knockouts and controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The negative acute-uptake result is retained; retention differences do not identify every influx or efflux pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pancreatic acinar cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f198b44f-83a6-53b5-9e9d-5819b51da364","evidence_kind":"source_excerpt","locator":"Lines 401-412","start_line":401,"end_line":412,"excerpt":"### zinc-trans-pancreas-zip5-retention\nPancreatic acinar-cell Zip5 deletion impaired retention of administered 67Zn despite no detected impairment of rapid pancreatic 67Zn accumulation.\nCondition category: machinery_impairment\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pancreatic ZIP5 helped retain zinc after uptake, rather than being required for the initial uptake measured here.\norganism: Mus musculus\ntissue_or_cell_type: Pancreatic acinar cells\nexperimental_model: Acinar-cell-specific knockout and 67Zn tracer kinetics\nlimitations: The negative acute-uptake result is retained; retention differences do not identify every influx or efflux pathway.\nexposure: Tracer zinc uptake and retention compared between acinar knockouts and controls.\ncross_nutrient: false\n[zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","model_system":"Acinar-cell-specific knockout and 67Zn tracer kinetics","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-24303081] The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity. (2013). https://pubmed.ncbi.nlm.nih.gov/24303081/ DOI: 10.1371/journal.pone.0082149","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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