Component
Odd-chain fatty acid synthesis
Odd-chain fatty acid synthesis
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Fatty-acid fragment labeling identified propionyl-CoA as the primer for odd-chain fatty-acid synthesis in 3T3-L1 adipocytes.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Full text Results; Figures 6-8 and isotope model
- experimental_model
- Differentiated mouse 3T3-L1 adipocytes
- exposure
- Parallel carbon-13 tracer and GC-MS fragment analysis
- limitations
- Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Mus musculus
- plain_language
- These mouse fat cells could divert the B12-pathway precursor into odd-chain fats.
- primary_references
- [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
- tissue_or_cell_type
- Adipocytes
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1244–1256
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Differentiated mouse 3T3-L1 adipocytes · source_derived_draft · unverified_draft
### propionyl-primes-odd-chain-fatty-acids Fatty-acid fragment labeling identified propionyl-CoA as the primer for odd-chain fatty-acid synthesis in 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: These mouse fat cells could divert the B12-pathway precursor into odd-chain fats. organism: Mus musculus tissue_or_cell_type: Adipocytes experimental_model: Differentiated mouse 3T3-L1 adipocytes limitations: Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions. exposure: Parallel carbon-13 tracer and GC-MS fragment analysis cross_nutrient: false evidence_location: Full text Results; Figures 6-8 and isotope model [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
Complete structured claim and evidence
Where it participates (unsigned role)
Carbon-13 isoleucine supplied lipogenic propionyl-CoA in cultured 3T3-L1 adipocytes.
Experimental context and source evidence
- cross_nutrient
- true
- evidence_location
- Full text Results; Figures 6-8 and isotope model
- experimental_model
- Differentiated mouse 3T3-L1 adipocytes
- exposure
- 24-hour [U-13C]isoleucine tracing
- limitations
- Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Mus musculus
- plain_language
- Mouse fat-cell tracing identified isoleucine as another source of the B12-pathway precursor.
- primary_references
- [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
- tissue_or_cell_type
- Adipocytes
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1230–1242
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Differentiated mouse 3T3-L1 adipocytes · source_derived_draft · unverified_draft
### isoleucine-propionyl-coa-lipogenesis Carbon-13 isoleucine supplied lipogenic propionyl-CoA in cultured 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mouse fat-cell tracing identified isoleucine as another source of the B12-pathway precursor. organism: Mus musculus tissue_or_cell_type: Adipocytes experimental_model: Differentiated mouse 3T3-L1 adipocytes limitations: Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions. exposure: 24-hour [U-13C]isoleucine tracing cross_nutrient: true evidence_location: Full text Results; Figures 6-8 and isotope model [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
Complete structured claim and evidenceCarbon-13 valine supplied the lipogenic propionyl-CoA precursor in cultured 3T3-L1 adipocytes.
Experimental context and source evidence
- cross_nutrient
- true
- evidence_location
- Full text Results; Figures 6-8 and isotope model
- experimental_model
- Differentiated mouse 3T3-L1 adipocytes
- exposure
- 24-hour [U-13C]valine tracing
- limitations
- Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Mus musculus
- plain_language
- Mouse fat-cell tracing placed valine carbon into the precursor that can enter B12-dependent metabolism or odd-chain fat synthesis.
- primary_references
- [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
- tissue_or_cell_type
- Adipocytes
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1216–1228
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Differentiated mouse 3T3-L1 adipocytes · source_derived_draft · unverified_draft
### valine-propionyl-coa-lipogenesis Carbon-13 valine supplied the lipogenic propionyl-CoA precursor in cultured 3T3-L1 adipocytes. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mouse fat-cell tracing placed valine carbon into the precursor that can enter B12-dependent metabolism or odd-chain fat synthesis. organism: Mus musculus tissue_or_cell_type: Adipocytes experimental_model: Differentiated mouse 3T3-L1 adipocytes limitations: Mouse cell culture; isotope labeling and model assumptions do not establish human dietary carbon fractions. exposure: 24-hour [U-13C]valine tracing cross_nutrient: true evidence_location: Full text Results; Figures 6-8 and isotope model [crown-2015-bcaa-fatty-acids] Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes. (2015). https://pubmed.ncbi.nlm.nih.gov/26710334/ DOI: 10.1371/journal.pone.0145850
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.