Component
Neural tube defect recurrence
Neural tube defect recurrence. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Among randomized PONTI pregnancies, NTD recurrence occurred in 0/14 with inositol plus folic acid versus 1/19 with placebo plus folic acid.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/inositol-research/26847388.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82", "start_char": 0, "end_char": 1680, "text_sha256": "a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82"}
- experimental_model
- PONTI double-blind randomized pilot with separately described nonrandomized pregnancies
- exposure
- Periconceptional inositol plus folic acid versus folic acid plus placebo
- limitations
- 47 women randomized; only 33 randomized pregnancies. The pilot was not powered to establish prevention. Corrigendum PMID 26917444 corrects the separate nonrandomized pregnancy count from 22 to 24; randomized counts used here are unchanged. Nonrandomized outcomes must not be pooled as randomized evidence.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Homo sapiens
- plain_language
- The pilot supported further study but was far too small to establish efficacy or replace folic acid.
- primary_references
- [ino-p26847388] Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. (2016). https://pubmed.ncbi.nlm.nih.gov/26847388/ DOI: 10.1017/s0007114515005322
- tissue_or_cell_type
- Women with a prior neural-tube-defect pregnancy
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1406–1417
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · PONTI double-blind randomized pilot with separately described nonrandomized pregnancies · source_derived_draft · unverified_draft
### ino-ponti Among randomized PONTI pregnancies, NTD recurrence occurred in 0/14 with inositol plus folic acid versus 1/19 with placebo plus folic acid. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The pilot supported further study but was far too small to establish efficacy or replace folic acid. organism: Homo sapiens tissue_or_cell_type: Women with a prior neural-tube-defect pregnancy experimental_model: PONTI double-blind randomized pilot with separately described nonrandomized pregnancies limitations: 47 women randomized; only 33 randomized pregnancies. The pilot was not powered to establish prevention. Corrigendum PMID 26917444 corrects the separate nonrandomized pregnancy count from 22 to 24; randomized counts used here are unchanged. Nonrandomized outcomes must not be pooled as randomized evidence. exposure: Periconceptional inositol plus folic acid versus folic acid plus placebo evidence_span: {"source_cache": "artifacts/inositol-research/26847388.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82", "start_char": 0, "end_char": 1680, "text_sha256": "a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82"} [ino-p26847388] Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. (2016). https://pubmed.ncbi.nlm.nih.gov/26847388/ DOI: 10.1017/s0007114515005322
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.