{"id":"9ebedeb0-64fe-558f-9943-2b5d04fdf73e","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-ponti","predicate":"tested_for_prevention_of","statement":"Among randomized PONTI pregnancies, NTD recurrence occurred in 0/14 with inositol plus folic acid versus 1/19 with placebo plus folic acid.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5343bf44-0eb5-5949-9738-62cf7dd5a742","mechanism_event_label":"The pilot supported further study but was far too small to establish efficacy or replace folic acid.","subject":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"object":{"id":"31331dbf-ab95-5a09-ba3a-549d86d3b192","slug":"ntd-recurrence","display_name":"Neural tube defect recurrence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5343bf44-0eb5-5949-9738-62cf7dd5a742","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-ponti-event","event_type":"observed_intervention","label":"The pilot supported further study but was far too small to establish efficacy or replace folic acid.","description":"Among randomized PONTI pregnancies, NTD recurrence occurred in 0/14 with inositol plus folic acid versus 1/19 with placebo plus folic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"both_groups","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"31331dbf-ab95-5a09-ba3a-549d86d3b192","slug":"ntd-recurrence","display_name":"Neural tube defect recurrence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/26847388.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82\", \"start_char\": 0, \"end_char\": 1680, \"text_sha256\": \"a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"PONTI double-blind randomized pilot with separately described nonrandomized pregnancies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Periconceptional inositol plus folic acid versus folic acid plus placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"47 women randomized; only 33 randomized pregnancies. The pilot was not powered to establish prevention. Corrigendum PMID 26917444 corrects the separate nonrandomized pregnancy count from 22 to 24; randomized counts used here are unchanged. Nonrandomized outcomes must not be pooled as randomized evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The pilot supported further study but was far too small to establish efficacy or replace folic acid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p26847388] Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. (2016). https://pubmed.ncbi.nlm.nih.gov/26847388/ DOI: 10.1017/s0007114515005322","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Women with a prior neural-tube-defect pregnancy","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"60d65ba9-26fb-5ec2-b8fc-3ef1b672a722","evidence_kind":"source_excerpt","locator":"Lines 1406-1417","start_line":1406,"end_line":1417,"excerpt":"### ino-ponti\nAmong randomized PONTI pregnancies, NTD recurrence occurred in 0/14 with inositol plus folic acid versus 1/19 with placebo plus folic acid.\nCondition category: normal\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pilot supported further study but was far too small to establish efficacy or replace folic acid.\norganism: Homo sapiens\ntissue_or_cell_type: Women with a prior neural-tube-defect pregnancy\nexperimental_model: PONTI double-blind randomized pilot with separately described nonrandomized pregnancies\nlimitations: 47 women randomized; only 33 randomized pregnancies. The pilot was not powered to establish prevention. Corrigendum PMID 26917444 corrects the separate nonrandomized pregnancy count from 22 to 24; randomized counts used here are unchanged. Nonrandomized outcomes must not be pooled as randomized evidence.\nexposure: Periconceptional inositol plus folic acid versus folic acid plus placebo\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/26847388.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82\", \"start_char\": 0, \"end_char\": 1680, \"text_sha256\": \"a7617d160ca71553f41ce2a7346478950ed9580a4bc9cca9688d3b710ec0cf82\"}\n[ino-p26847388] Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. (2016). https://pubmed.ncbi.nlm.nih.gov/26847388/ DOI: 10.1017/s0007114515005322","model_system":"PONTI double-blind randomized pilot with separately described nonrandomized pregnancies","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p26847388] Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. (2016). https://pubmed.ncbi.nlm.nih.gov/26847388/ DOI: 10.1017/s0007114515005322","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f7adbcedad647d5f8a3cc9e46bfa515e83c508be9c2a4e9d59c5f5dfb0667d53","revision_id":"a82d187c-60fb-52d1-8482-eadb92860f33","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}