Component
NIS basolateral membrane targeting
Sorting of NIS protein to the basolateral membrane of polarized epithelial cells.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Depletion of the AP-1B mu1B subunit in polarized MDCK cells caused expressed human NIS to be missorted toward the apical membrane while retaining transport function.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Human NIS expressed in canine MDCK epithelial cells with AP-1 adaptor subunit silencing
- exposure
- AP-1B mu1B silencing compared with control MDCK-hNIS cells.
- limitations
- Engineered epithelial model; apical uptake does not establish useful blood-to-thyroid delivery in vivo.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Human NIS in canine MDCK cells
- plain_language
- Correct membrane placement depends on the cell’s sorting machinery.
- primary_references
- [iodine-trans-sorting2022] Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes. (2022). https://pubmed.ncbi.nlm.nih.gov/35833460/ DOI: 10.1089/thy.2022.0163
- tissue_or_cell_type
- Polarized epithelial plasma membrane
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 206–217
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human NIS expressed in canine MDCK epithelial cells with AP-1 adaptor subunit silencing · source_derived_draft · unverified_draft
### iodine-trans-ap1b-polarity Depletion of the AP-1B mu1B subunit in polarized MDCK cells caused expressed human NIS to be missorted toward the apical membrane while retaining transport function. Condition category: machinery_impairment nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Correct membrane placement depends on the cell’s sorting machinery. organism: Human NIS in canine MDCK cells tissue_or_cell_type: Polarized epithelial plasma membrane experimental_model: Human NIS expressed in canine MDCK epithelial cells with AP-1 adaptor subunit silencing limitations: Engineered epithelial model; apical uptake does not establish useful blood-to-thyroid delivery in vivo. exposure: AP-1B mu1B silencing compared with control MDCK-hNIS cells. cross_nutrient: false [iodine-trans-sorting2022] Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes. (2022). https://pubmed.ncbi.nlm.nih.gov/35833460/ DOI: 10.1089/thy.2022.0163
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.