Component
NFAT cytoplasmic subunit nuclear translocation
Movement of the pre-existing cytoplasmic NFAT subunit into the nucleus on antigen-receptor signalling, which is the step cyclosporine blocks.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the cytoplasmic component.
Experimental context and source evidence
- duration
- Not stated here
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- T lymphocytes
- exposure
- Cyclosporin A; FK506 compared alongside
- limitations
- Synthesis of the nuclear subunit was not affected, so the block is on translocation rather than on making the factor. The abstract does not give concentrations or a time course.
- organism
- T lymphocytes
- plain_language
- NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the cytoplasmic component.
- primary_references
- Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. (1991). https://pubmed.ncbi.nlm.nih.gov/1715516/ DOI: 10.1038/352803a0
- route
- In vitro
- tissue
- Antigen-receptor signalling to cytokine genes
Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23) · lines 102–102
Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text. · supports · T lymphocytes · source_derived_draft · unverified_draft
NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the cytoplasmic component.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.