{"id":"2b886f84-65a7-5072-a677-550c9c0acadc","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-blocks-nfat-nuclear-translocation","predicate":"blocks","statement":"NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the cytoplasmic component.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d46335d8-eb8e-5a47-8b76-bb0e098d3289","mechanism_event_label":"NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the ","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"6cf047c4-625b-5d95-9864-35da3f39cb2e","slug":"nfat-nuclear-translocation","display_name":"NFAT cytoplasmic subunit nuclear translocation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d46335d8-eb8e-5a47-8b76-bb0e098d3289","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-blocks-nfat-nuclear-translocation-event","event_type":"biochemical_relationship","label":"NFAT is assembled when an antigen-receptor signal drives a pre-existing cytoplasmic subunit into the nucleus to join a newly synthesised nuclear subunit, and cyclosporin A blocks translocation of the ","description":"Antigen-receptor signalling to cytokine genes","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6cf047c4-625b-5d95-9864-35da3f39cb2e","slug":"nfat-nuclear-translocation","display_name":"NFAT cytoplasmic subunit nuclear translocation","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"T lymphocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyclosporin A; FK506 compared alongside","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Synthesis of the nuclear subunit was not affected, so the block is on translocation rather than on making the factor. 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No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}