Component
New renal-replacement therapy
New renal-replacement therapy. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
New renal-replacement therapy occurred in 12.7% versus 12.9%; the difference confidence interval included zero.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/35041780.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70", "start_char": 0, "end_char": 2031, "text_sha256": "93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70"}
- experimental_model
- PLUS double-blind randomized trial
- exposure
- Plasma-Lyte 148 versus saline
- limitations
- Different primary outcome and design from SMART; a nonsignificant difference does not prove equivalence or isolate chloride.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- 5,037 critically ill adults
- plain_language
- The later trial also did not show a clear dialysis benefit.
- primary_references
- [chloride-p35041780] Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35041780/ DOI: 10.1056/nejmoa2114464
- tissue_or_cell_type
- 53 Australian/New Zealand ICUs
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 1030–1041
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · PLUS double-blind randomized trial · source_derived_draft · unverified_draft
### chloride-plus-rrt New renal-replacement therapy occurred in 12.7% versus 12.9%; the difference confidence interval included zero. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The later trial also did not show a clear dialysis benefit. organism: 5,037 critically ill adults tissue_or_cell_type: 53 Australian/New Zealand ICUs experimental_model: PLUS double-blind randomized trial limitations: Different primary outcome and design from SMART; a nonsignificant difference does not prove equivalence or isolate chloride. exposure: Plasma-Lyte 148 versus saline evidence_span: {"source_cache": "artifacts/chloride-research/35041780.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70", "start_char": 0, "end_char": 2031, "text_sha256": "93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70"} [chloride-p35041780] Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35041780/ DOI: 10.1056/nejmoa2114464
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.