{"id":"1bdc42ed-baee-5abb-93e3-427690e54ed1","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-plus-rrt","predicate":"no_detected_effect_on","statement":"New renal-replacement therapy occurred in 12.7% versus 12.9%; the difference confidence interval included zero.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"781b13aa-6c1f-5bdc-a80c-c78ae8a36313","mechanism_event_label":"The later trial also did not show a clear dialysis benefit.","subject":{"id":"a3c76578-787f-5465-bbc6-6a8bb874099c","slug":"balanced-crystalloids","display_name":"Balanced crystalloid intravenous solutions (formulation specified per claim)","entity_type_key":"chemical_species"},"object":{"id":"2582dd48-c26c-5f20-9c5c-5476a4c107d6","slug":"new-renal-replacement-therapy","display_name":"New renal-replacement therapy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"781b13aa-6c1f-5bdc-a80c-c78ae8a36313","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-plus-rrt-event","event_type":"observed_intervention","label":"The later trial also did not show a clear dialysis benefit.","description":"New renal-replacement therapy occurred in 12.7% versus 12.9%; the difference confidence interval included zero.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3c76578-787f-5465-bbc6-6a8bb874099c","slug":"balanced-crystalloids","display_name":"Balanced crystalloid intravenous solutions (formulation specified per claim)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2582dd48-c26c-5f20-9c5c-5476a4c107d6","slug":"new-renal-replacement-therapy","display_name":"New renal-replacement therapy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/35041780.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70\", \"start_char\": 0, \"end_char\": 2031, \"text_sha256\": \"93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"PLUS double-blind randomized trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Plasma-Lyte 148 versus saline","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different primary outcome and design from SMART; a nonsignificant difference does not prove equivalence or isolate chloride.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"5,037 critically ill adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The later trial also did not show a clear dialysis benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p35041780] Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35041780/ DOI: 10.1056/nejmoa2114464","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"53 Australian/New Zealand ICUs","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4398d78d-8a86-54e5-b4bc-bdb508a4d139","evidence_kind":"source_excerpt","locator":"Lines 1030-1041","start_line":1030,"end_line":1041,"excerpt":"### chloride-plus-rrt\nNew renal-replacement therapy occurred in 12.7% versus 12.9%; the difference confidence interval included zero.\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The later trial also did not show a clear dialysis benefit.\norganism: 5,037 critically ill adults\ntissue_or_cell_type: 53 Australian/New Zealand ICUs\nexperimental_model: PLUS double-blind randomized trial\nlimitations: Different primary outcome and design from SMART; a nonsignificant difference does not prove equivalence or isolate chloride.\nexposure: Plasma-Lyte 148 versus saline\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/35041780.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70\", \"start_char\": 0, \"end_char\": 2031, \"text_sha256\": \"93fd07a116ddc28d056e36eb8aa72edd0666af1d402fe9a297fc5698d9d62e70\"}\n[chloride-p35041780] Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35041780/ DOI: 10.1056/nejmoa2114464","model_system":"PLUS double-blind randomized trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chloride-p35041780] Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35041780/ DOI: 10.1056/nejmoa2114464","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1c2070d5-9f15-5945-b325-d0b49a32c04b","stable_key":"import-4df6a932-097e-563a-91fe-5dceec471ffd","title":"Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e32e796f293a3287c6b8f4394881db94cc741ba96e3166e44da2dd14f208f645","revision_id":"8d5fd8ef-db54-5198-a368-23329a02d81b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}