Component
Native ATP-evoked P2X current in adult neurons
Fast ATP-evoked inward current in trigeminal mesencephalic and hippocampal CA1 neurons.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ivermectin produced no significant effect on fast ATP-evoked inward currents in adult trigeminal mesencephalic nucleus or hippocampal CA1 neurons.
Experimental context and source evidence
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Adult rat trigeminal mesencephalic nucleus and hippocampal CA1 neurons
- exposure
- Ivermectin at concentrations that modulated heterologously expressed P2X4
- limitations
- The authors read this as evidence that homomeric P2X4 is not the primary P2X subtype in these neurons, not as evidence that ivermectin fails to reach the channel.
- organism
- Adult rat trigeminal mesencephalic nucleus and hippocampal CA1 neurons
- plain_language
- Ivermectin produced no significant effect on fast ATP-evoked inward currents in adult trigeminal mesencephalic nucleus or hippocampal CA1 neurons.
- primary_references
- Allosteric control of gating and kinetics at P2X(4) receptor channels. (1999). https://pubmed.ncbi.nlm.nih.gov/10460235/ DOI: 10.1523/JNEUROSCI.19-17-07289.1999
- route
- In vitro
- tissue
- Endogenously expressed P2X receptor currents
Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22) · lines 101–110
Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## ivermectin-native-p2x-current-null Ivermectin produced no significant effect on fast ATP-evoked inward currents in adult trigeminal mesencephalic nucleus or hippocampal CA1 neurons. Model/species: Adult rat trigeminal mesencephalic nucleus and hippocampal CA1 neurons Tissue/system: Endogenously expressed P2X receptor currents Exposure: Ivermectin at concentrations that modulated heterologously expressed P2X4 Route: In vitro Duration: Acute Limits: The authors read this as evidence that homomeric P2X4 is not the primary P2X subtype in these neurons, not as evidence that ivermectin fails to reach the channel. Primary reference: Allosteric control of gating and kinetics at P2X(4) receptor channels. (1999). https://pubmed.ncbi.nlm.nih.gov/10460235/ DOI: 10.1523/JNEUROSCI.19-17-07289.1999 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.