Component
Myocardial infarction incidence
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
An older-women calcium trial showed an upward myocardial-infarction signal that weakened when registry events were added.
Experimental context and source evidence
- experimental_model
- 1471 postmenopausal women, five-year randomized trial; secondary cardiovascular analysis.
- exposure
- Calcium citrate tablets versus placebo in the parent randomized trial; calcium-only intervention, not the WHI calcium-plus-vitamin-D regimen.
- limitations
- Adjudicated reported MI RR 2.12 (1.01-4.47); including unreported registry events RR 1.49 (0.86-2.57). Does not establish vascular calcification as the mediator.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- The heart-event result depended partly on how events were collected.
- primary_references
- [cal-clin-bolland2008] Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial (2008). https://pubmed.ncbi.nlm.nih.gov/18198394/ DOI: 10.1136/bmj.39440.525752.BE
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1281–1291
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 1471 postmenopausal women, five-year randomized trial; secondary cardiovascular analysis. · source_derived_draft · unverified_draft
### cal-bolland-myocardial-events An older-women calcium trial showed an upward myocardial-infarction signal that weakened when registry events were added. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The heart-event result depended partly on how events were collected. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 1471 postmenopausal women, five-year randomized trial; secondary cardiovascular analysis. limitations: Adjudicated reported MI RR 2.12 (1.01-4.47); including unreported registry events RR 1.49 (0.86-2.57). Does not establish vascular calcification as the mediator. exposure: Calcium citrate tablets versus placebo in the parent randomized trial; calcium-only intervention, not the WHI calcium-plus-vitamin-D regimen. [cal-clin-bolland2008] Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial (2008). https://pubmed.ncbi.nlm.nih.gov/18198394/ DOI: 10.1136/bmj.39440.525752.BE
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.