Component
ATP-dependent MRP1 glutathione-disulfide transport
ATP-dependent MRP1 glutathione-disulfide transport. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MRP1 mediated ATP-dependent GSSG transport; the HeLa-vesicle Km was 93 ± 26 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/8670053.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9178e466ea8bd18f0957cc65594934ec1681ad7483e6ac64d79c4b8d8ca2afc3", "start_char": 0, "end_char": 1433, "text_sha256": "9178e466ea8bd18f0957cc65594934ec1681ad7483e6ac64d79c4b8d8ca2afc3"}
- experimental_model
- Membrane-vesicle transport assays
- exposure
- ATP-dependent GSSG uptake into vesicles
- limitations
- Vesicle uptake reflects cellular export; the GSH null result applies specifically to the tested 100 micromolar condition.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human HL60 and HeLa systems
- plain_language
- Oxidized glutathione can be exported instead of recycled locally.
- primary_references
- [glutathione-p8670053] ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. (1996). https://pubmed.ncbi.nlm.nih.gov/8670053/ DOI: 10.1042/bj3140433
- tissue_or_cell_type
- MRP-overexpressing membranes
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 723–734
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Membrane-vesicle transport assays · source_derived_draft · unverified_draft
### glutathione-mrp-gssg MRP1 mediated ATP-dependent GSSG transport; the HeLa-vesicle Km was 93 ± 26 micromolar. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Oxidized glutathione can be exported instead of recycled locally. organism: Human HL60 and HeLa systems tissue_or_cell_type: MRP-overexpressing membranes experimental_model: Membrane-vesicle transport assays limitations: Vesicle uptake reflects cellular export; the GSH null result applies specifically to the tested 100 micromolar condition. exposure: ATP-dependent GSSG uptake into vesicles evidence_span: {"source_cache": "artifacts/glutathione-research/8670053.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9178e466ea8bd18f0957cc65594934ec1681ad7483e6ac64d79c4b8d8ca2afc3", "start_char": 0, "end_char": 1433, "text_sha256": "9178e466ea8bd18f0957cc65594934ec1681ad7483e6ac64d79c4b8d8ca2afc3"} [glutathione-p8670053] ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. (1996). https://pubmed.ncbi.nlm.nih.gov/8670053/ DOI: 10.1042/bj3140433
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.