Component
Experimental TRPM8-deficient mouse genotype
Experimental TRPM8-deficient mouse genotype. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
TRPM8-deficient animals showed clear behavioural deficits in discriminating between cold and warm surfaces and in responding to evaporative cooling, while still avoiding surfaces below 10 degrees C with reduced efficiency.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"}
- experimental_model
- TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour
- exposure
- Ambient cooling below about 26 degrees C; menthol as a chemical agonist
- limitations
- A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Mouse
- plain_language
- Without the channel the animal cannot tell cold from warm, though extreme cold still registers somehow.
- primary_references
- [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
- tissue_or_cell_type
- Primary afferent sensory neurons
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 78–89
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour · source_derived_draft · unverified_draft
### cold-trpm8-null-behaviour TRPM8-deficient animals showed clear behavioural deficits in discriminating between cold and warm surfaces and in responding to evaporative cooling, while still avoiding surfaces below 10 degrees C with reduced efficiency. Condition category: machinery_impairment nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Without the channel the animal cannot tell cold from warm, though extreme cold still registers somehow. organism: Mouse tissue_or_cell_type: Primary afferent sensory neurons experimental_model: TRPM8-deficient mice with cultured sensory neurons, intact nerve fibre recording and behaviour limitations: A genetic loss-of-function study. TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector. exposure: Ambient cooling below about 26 degrees C; menthol as a chemical agonist evidence_span: {"source_cache": "artifacts/cold-research/17538622.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300", "start_char": 0, "end_char": 1451, "text_sha256": "94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300"} [cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. (2007). https://pubmed.ncbi.nlm.nih.gov/17538622/ DOI: 10.1038/nature05910
Complete structured claim and evidence
Where it participates (unsigned role)
M8-B decreased deep body temperature in Trpm8-positive mice and rats but not in Trpm8-null mice, and intravenous administration was more effective than intrathecal or intracerebroventricular, indicating a peripheral action.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/cold-research/22323721.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0", "start_char": 0, "end_char": 1784, "text_sha256": "c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0"}
- experimental_model
- Rats and mice with a selective TRPM8 antagonist given by several routes
- exposure
- M8-B intravenously, intrathecally or intracerebroventricularly, at constant or changing ambient temperature
- limitations
- On-target action is supported by the absence of effect in Trpm8-null mice. The peripheral site of action is inferred from route comparison, not from direct measurement at the nerve ending.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Rat, mouse and human channels in vitro
- plain_language
- Blocking the skin cold sensor makes the body cool down, because it never learns it is cold.
- primary_references
- [cold-p22323721] Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. (2012). https://pubmed.ncbi.nlm.nih.gov/22323721/ DOI: 10.1523/jneurosci.5606-11.2012
- tissue_or_cell_type
- Skin sensory neurons and thermoeffectors
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 91–102
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rats and mice with a selective TRPM8 antagonist given by several routes · source_derived_draft · unverified_draft
### cold-trpm8-blockade-temperature M8-B decreased deep body temperature in Trpm8-positive mice and rats but not in Trpm8-null mice, and intravenous administration was more effective than intrathecal or intracerebroventricular, indicating a peripheral action. Condition category: machinery_impairment nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Blocking the skin cold sensor makes the body cool down, because it never learns it is cold. organism: Rat, mouse and human channels in vitro tissue_or_cell_type: Skin sensory neurons and thermoeffectors experimental_model: Rats and mice with a selective TRPM8 antagonist given by several routes limitations: On-target action is supported by the absence of effect in Trpm8-null mice. The peripheral site of action is inferred from route comparison, not from direct measurement at the nerve ending. exposure: M8-B intravenously, intrathecally or intracerebroventricularly, at constant or changing ambient temperature evidence_span: {"source_cache": "artifacts/cold-research/22323721.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0", "start_char": 0, "end_char": 1784, "text_sha256": "c0ead3b0097eaa75bf74d806e7f40bc61da4275cdd0af92735be9cad681ed3f0"} [cold-p22323721] Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. (2012). https://pubmed.ncbi.nlm.nih.gov/22323721/ DOI: 10.1523/jneurosci.5606-11.2012
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.