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TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Without the channel the animal cannot tell cold from warm, though extreme cold still registers somehow.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. 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TRPM8 mutant mice still avoid surfaces below 10 degrees C, so the channel is the principal but not the only cold detector.\nexposure: Ambient cooling below about 26 degrees C; menthol as a chemical agonist\nevidence_span: {\"source_cache\": \"artifacts/cold-research/17538622.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"94d6ed0e3d36f9530a7bb47b1635ee1fd438bb60aced91efd69d544b13d18300\"}\n[cold-p17538622] The menthol receptor TRPM8 is the principal detector of environmental cold. 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