Component
Mouse Trpm7 channel
Mouse Trpm7 channel. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
PLC-coupled agonists activated TRPM7 currents under perforated-patch conditions that preserved physiological intracellular ions.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/inositol-research/17095511.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83", "start_char": 0, "end_char": 1403, "text_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83"}
- experimental_model
- Perforated versus whole-cell patch clamp and FRET
- exposure
- PLC-coupled agonists with different intracellular magnesium conditions
- limitations
- The opposite current responses are explicitly explained by experimental ionic conditions; they are not an unresolved scientific contradiction.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Mouse N1E-115 neuroblastoma cells
- plain_language
- The channel response reversed when the cell’s internal environment was better preserved.
- primary_references
- [ino-p17095511] Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. (2007). https://pubmed.ncbi.nlm.nih.gov/17095511/ DOI: 10.1074/jbc.m605300200
- tissue_or_cell_type
- TRPM7-expressing cells
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 977–988
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Perforated versus whole-cell patch clamp and FRET · source_derived_draft · unverified_draft
### ino-trpm7-physiologic PLC-coupled agonists activated TRPM7 currents under perforated-patch conditions that preserved physiological intracellular ions. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The channel response reversed when the cell’s internal environment was better preserved. organism: Mouse N1E-115 neuroblastoma cells tissue_or_cell_type: TRPM7-expressing cells experimental_model: Perforated versus whole-cell patch clamp and FRET limitations: The opposite current responses are explicitly explained by experimental ionic conditions; they are not an unresolved scientific contradiction. exposure: PLC-coupled agonists with different intracellular magnesium conditions evidence_span: {"source_cache": "artifacts/inositol-research/17095511.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83", "start_char": 0, "end_char": 1403, "text_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83"} [ino-p17095511] Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. (2007). https://pubmed.ncbi.nlm.nih.gov/17095511/ DOI: 10.1074/jbc.m605300200
Complete structured claim and evidence
Where it participates (unsigned role)
PLC-dependent TRPM7 inhibition under whole-cell recording was observed only when intracellular Mg2+ was reduced below physiological levels.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/inositol-research/17095511.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83", "start_char": 0, "end_char": 1403, "text_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83"}
- experimental_model
- Perforated versus whole-cell patch clamp and FRET
- exposure
- PLC-coupled agonists with different intracellular magnesium conditions
- limitations
- The opposite current responses are explicitly explained by experimental ionic conditions; they are not an unresolved scientific contradiction.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Mouse N1E-115 neuroblastoma cells
- plain_language
- Changing magnesium inside the recorded cell changed how the channel responded.
- primary_references
- [ino-p17095511] Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. (2007). https://pubmed.ncbi.nlm.nih.gov/17095511/ DOI: 10.1074/jbc.m605300200
- tissue_or_cell_type
- TRPM7-expressing cells
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 964–975
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Perforated versus whole-cell patch clamp and FRET · source_derived_draft · unverified_draft
### ino-trpm7-low-mg PLC-dependent TRPM7 inhibition under whole-cell recording was observed only when intracellular Mg2+ was reduced below physiological levels. Condition category: nutrient_deficiency nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing magnesium inside the recorded cell changed how the channel responded. organism: Mouse N1E-115 neuroblastoma cells tissue_or_cell_type: TRPM7-expressing cells experimental_model: Perforated versus whole-cell patch clamp and FRET limitations: The opposite current responses are explicitly explained by experimental ionic conditions; they are not an unresolved scientific contradiction. exposure: PLC-coupled agonists with different intracellular magnesium conditions evidence_span: {"source_cache": "artifacts/inositol-research/17095511.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83", "start_char": 0, "end_char": 1403, "text_sha256": "28346917b1f99a6c832092a0ff4d39cb2906a680e5e18257412a19ba289d6c83"} [ino-p17095511] Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. (2007). https://pubmed.ncbi.nlm.nih.gov/17095511/ DOI: 10.1074/jbc.m605300200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.