Component
Mouse spermatogonial differentiation
Developmental progression of undifferentiated spermatogonia in the testis.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Dietary vitamin A depletion caused undifferentiated spermatogonia to accumulate in prepubertal Lrat-null testes.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Genotype-by-diet mouse comparison
- exposure
- Maternal vitamin A-free diet from E0.5 through lactation; neonatal endpoints through P18.
- limitations
- Storage-defective background accelerated depletion; this is not a knockout-only effect.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Vitamin A shortage can stop early sperm-cell differentiation.
- primary_references
- [li2011] Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. (2011). https://pubmed.ncbi.nlm.nih.gov/20881313/ DOI: 10.1095/biolreprod.110.086157
- tissue_or_cell_type
- prepubertal testis
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 265–276
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genotype-by-diet mouse comparison · source_derived_draft · unverified_draft
### va-repro-vitamin-a-withdrawal Dietary vitamin A depletion caused undifferentiated spermatogonia to accumulate in prepubertal Lrat-null testes. Condition category: nutrient_deficiency nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Vitamin A shortage can stop early sperm-cell differentiation. organism: Mus musculus tissue_or_cell_type: prepubertal testis experimental_model: Genotype-by-diet mouse comparison limitations: Storage-defective background accelerated depletion; this is not a knockout-only effect. exposure: Maternal vitamin A-free diet from E0.5 through lactation; neonatal endpoints through P18. cross_nutrient: false [li2011] Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. (2011). https://pubmed.ncbi.nlm.nih.gov/20881313/ DOI: 10.1095/biolreprod.110.086157
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.