Component
Excitatory responses of mouse substantia-nigra dopamine neurons
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
D-aspartate excited mouse nigral dopamine neurons with NMDA, AMPA and metabotropic receptor-sensitive components.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse substantia nigra pars compacta slice electrophysiology.
- limitations
- Antagonist-sensitive responses do not by themselves prove direct agonism at every receptor; indirect glutamate release can contribute.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- Several receptor pathways contribute to the observed electrical response.
- primary_references
- Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 192–198
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse substantia nigra pars compacta slice electrophysiology. · source_derived_draft · unverified_draft
## d-aspartate-nigral-excitation Several receptor pathways contribute to the observed electrical response. D-aspartate excited mouse nigral dopamine neurons with NMDA, AMPA and metabotropic receptor-sensitive components. Model: Mouse substantia nigra pars compacta slice electrophysiology. Limitations: Antagonist-sensitive responses do not by themselves prove direct agonism at every receptor; indirect glutamate release can contribute. Evidence access: Primary abstract Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013
Complete structured claim and evidenceEAAT inhibition strongly potentiated D-aspartate-evoked, but not L-aspartate-evoked, currents in Ddo-knockout mouse neurons.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Ddo-knockout mouse nigral neuron transporter-blocker experiments.
- limitations
- A protective adaptation is an interpretation; human transporter failure and dietary consequences were not tested.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- Uptake can buffer excitation when breakdown is impaired.
- primary_references
- Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 208–214
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Ddo-knockout mouse nigral neuron transporter-blocker experiments. · source_derived_draft · unverified_draft
## d-aspartate-uptake-buffer Uptake can buffer excitation when breakdown is impaired. EAAT inhibition strongly potentiated D-aspartate-evoked, but not L-aspartate-evoked, currents in Ddo-knockout mouse neurons. Model: Ddo-knockout mouse nigral neuron transporter-blocker experiments. Limitations: A protective adaptation is an interpretation; human transporter failure and dietary consequences were not tested. Evidence access: Primary abstract Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.