{"id":"15d66cb4-839c-5da4-a189-94413ebf39fe","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-nigral-excitation","predicate":"excites","statement":"D-aspartate excited mouse nigral dopamine neurons with NMDA, AMPA and metabotropic receptor-sensitive components.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"67907f82-8761-511d-aa7b-2b389d610f08","mechanism_event_label":"Several receptor pathways contribute to the observed electrical response.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"57d4b728-4620-552d-8fd3-a7e90bccbbea","slug":"mouse-snc-dopamine-neuron-response","display_name":"Excitatory responses of mouse substantia-nigra dopamine neurons","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"67907f82-8761-511d-aa7b-2b389d610f08","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-nigral-excitation-event","event_type":"observed_relationship","label":"Several receptor pathways contribute to the observed electrical response.","description":"D-aspartate excited mouse nigral dopamine neurons with NMDA, AMPA and metabotropic receptor-sensitive components.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57d4b728-4620-552d-8fd3-a7e90bccbbea","slug":"mouse-snc-dopamine-neuron-response","display_name":"Excitatory responses of mouse substantia-nigra dopamine neurons","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse substantia nigra pars compacta slice electrophysiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Antagonist-sensitive responses do not by themselves prove direct agonism at every receptor; indirect glutamate release can contribute.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Several receptor pathways contribute to the observed electrical response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a88500bd-dceb-5f11-b18c-e13d9ef7662d","evidence_kind":"source_excerpt","locator":"Lines 192-198","start_line":192,"end_line":198,"excerpt":"## d-aspartate-nigral-excitation\nSeveral receptor pathways contribute to the observed electrical response.\nD-aspartate excited mouse nigral dopamine neurons with NMDA, AMPA and metabotropic receptor-sensitive components.\nModel: Mouse substantia nigra pars compacta slice electrophysiology.\nLimitations: Antagonist-sensitive responses do not by themselves prove direct agonism at every receptor; indirect glutamate release can contribute.\nEvidence access: Primary abstract\nPersistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26707656/ · DOI 10.1016/j.neuropharm.2015.12.013","model_system":"Mouse substantia nigra pars compacta slice electrophysiology.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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