Component
Mouse SMAD3
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Tregs promoted NFAT1-SMAD3 complex assembly in mouse CD8 cells, driving Wnt10b expression in the butyrate-associated bone pathway.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse CD8/Treg mechanistic experiments.
- limitations
- NFAT1 is Nfatc2, not the osteoclast NFATc1 protein.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Two transcription factors linked the immune relay to a bone-building ligand.
- primary_references
- The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30446387/ · DOI 10.1016/j.immuni.2018.10.013
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 462–468
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse CD8/Treg mechanistic experiments. · source_derived_draft · unverified_draft
## butyrate-wnt-transcription-complex Two transcription factors linked the immune relay to a bone-building ligand. Tregs promoted NFAT1-SMAD3 complex assembly in mouse CD8 cells, driving Wnt10b expression in the butyrate-associated bone pathway. Model: Mouse CD8/Treg mechanistic experiments. Limitations: NFAT1 is Nfatc2, not the osteoclast NFATc1 protein. Evidence access: Primary abstract The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30446387/ · DOI 10.1016/j.immuni.2018.10.013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.