Component

Mouse creatine transporter / Slc6a8

Mouse creatine transporter / Slc6a8. Species, exposure and limitations are retained in each linked claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Loss of Slc6a8 impaired CD8 T-cell antitumor immunity in the studied mouse models.

    Mouse creatine transporter / Slc6a8 → Antitumor T-cell function in mouse models source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"}
    experimental_model
    Transporter-deficient T cells, tumor models and supplementation experiments
    exposure
    Slc6a8 deletion; creatine administration with or without checkpoint blockade
    limitations
    Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    Having creatine available outside cells did not replace the missing transporter.
    primary_references
    [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    tissue_or_cell_type
    CD8 T cells and transplanted tumor models
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 581–592

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-deficient T cells, tumor models and supplementation experiments · source_derived_draft · unverified_draft

    ### creatine-tumor-transporter-loss Loss of Slc6a8 impaired CD8 T-cell antitumor immunity in the studied mouse models. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Having creatine available outside cells did not replace the missing transporter. organism: Mice tissue_or_cell_type: CD8 T cells and transplanted tumor models experimental_model: Transporter-deficient T cells, tumor models and supplementation experiments limitations: Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred. exposure: Slc6a8 deletion; creatine administration with or without checkpoint blockade evidence_span: {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"} [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. CRT loss impaired epithelial barrier formation and wound healing; transporter-deficient organoids also had reduced barrier function.

    Human creatine transporter CRT / SLC6A8 → Intestinal epithelial barrier integrity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/32433978.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887", "start_char": 0, "end_char": 2283, "text_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887"}
    experimental_model
    Transporter manipulation, intestinal organoids and human biopsy comparison
    exposure
    CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies
    limitations
    Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Human T84 cells, mouse organoids and human IBD biopsies
    plain_language
    Intestinal cells needed the transporter to maintain their barrier in these experiments.
    primary_references
    [creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. (2020). https://pubmed.ncbi.nlm.nih.gov/32433978/ DOI: 10.1053/j.gastro.2020.05.033
    tissue_or_cell_type
    Intestinal epithelium and tight junctions
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 646–657

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter manipulation, intestinal organoids and human biopsy comparison · source_derived_draft · unverified_draft

    ### creatine-gut-transporter-barrier CRT loss impaired epithelial barrier formation and wound healing; transporter-deficient organoids also had reduced barrier function. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Intestinal cells needed the transporter to maintain their barrier in these experiments. organism: Human T84 cells, mouse organoids and human IBD biopsies tissue_or_cell_type: Intestinal epithelium and tight junctions experimental_model: Transporter manipulation, intestinal organoids and human biopsy comparison limitations: Causal epithelial experiments and observational human expression findings are distinct; no human creatine treatment outcome was tested. exposure: CRT knockdown/overexpression; transporter-deficient organoids; 30 Crohn disease, 27 ulcerative colitis and 30 control biopsies evidence_span: {"source_cache": "artifacts/creatine-research/32433978.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887", "start_char": 0, "end_char": 2283, "text_sha256": "1733708b77e75d099fa25665b9b9a9aa0af72143c985b6f0f2b931fb8f4c0887"} [creatine-p32433978] Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. (2020). https://pubmed.ncbi.nlm.nih.gov/32433978/ DOI: 10.1053/j.gastro.2020.05.033
    Complete structured claim and evidence

  2. Ckb or Slc6a8 loss impaired T-cell function without changing global adenylate energy charge in the study.

    Mouse creatine kinase B / Ckb → T-cell adenylate energy charge source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"}
    experimental_model
    Transporter or kinase loss, T-cell homeostasis and infection experiments
    exposure
    Slc6a8 or Ckb deletion
    limitations
    The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    The observed signaling defect could not be reduced to a simple fall in the cell-wide energy measurement.
    primary_references
    [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    tissue_or_cell_type
    Naive and activated CD8 T cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 633–644

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter or kinase loss, T-cell homeostasis and infection experiments · source_derived_draft · unverified_draft

    ### creatine-tcell-energy-charge Ckb or Slc6a8 loss impaired T-cell function without changing global adenylate energy charge in the study. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The observed signaling defect could not be reduced to a simple fall in the cell-wide energy measurement. organism: Mice tissue_or_cell_type: Naive and activated CD8 T cells experimental_model: Transporter or kinase loss, T-cell homeostasis and infection experiments limitations: The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements. exposure: Slc6a8 or Ckb deletion evidence_span: {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"} [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    Complete structured claim and evidence

  3. Loss of either Ckb or Slc6a8 compromised CD8 T-cell expansion in response to infection.

    Mouse creatine kinase B / Ckb → CD8 T-cell expansion in response to infection source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"}
    experimental_model
    Transporter or kinase loss, T-cell homeostasis and infection experiments
    exposure
    Slc6a8 or Ckb deletion
    limitations
    The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    Both the transporter and the phosphate-transfer enzyme mattered for the immune response.
    primary_references
    [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    tissue_or_cell_type
    Naive and activated CD8 T cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 607–618

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter or kinase loss, T-cell homeostasis and infection experiments · source_derived_draft · unverified_draft

    ### creatine-tcell-expansion-loss Loss of either Ckb or Slc6a8 compromised CD8 T-cell expansion in response to infection. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both the transporter and the phosphate-transfer enzyme mattered for the immune response. organism: Mice tissue_or_cell_type: Naive and activated CD8 T cells experimental_model: Transporter or kinase loss, T-cell homeostasis and infection experiments limitations: The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements. exposure: Slc6a8 or Ckb deletion evidence_span: {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"} [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    Complete structured claim and evidence

  4. Ckb or Slc6a8 loss weakened TCR-mediated mTORC1 activation required for CD8 T-cell expansion.

    Mouse creatine kinase B / Ckb → Mechanistic target of rapamycin complex 1 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"}
    experimental_model
    Transporter or kinase loss, T-cell homeostasis and infection experiments
    exposure
    Slc6a8 or Ckb deletion
    limitations
    The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    The pathway also affected the signal telling T cells to expand.
    primary_references
    [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    tissue_or_cell_type
    Naive and activated CD8 T cells
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 620–631

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter or kinase loss, T-cell homeostasis and infection experiments · source_derived_draft · unverified_draft

    ### creatine-tcell-mtor-loss Ckb or Slc6a8 loss weakened TCR-mediated mTORC1 activation required for CD8 T-cell expansion. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The pathway also affected the signal telling T cells to expand. organism: Mice tissue_or_cell_type: Naive and activated CD8 T cells experimental_model: Transporter or kinase loss, T-cell homeostasis and infection experiments limitations: The study distinguishes TCR–mTORC1 signaling from whole-cell adenylate energy charge; it does not demonstrate clinical immune benefits of supplements. exposure: Slc6a8 or Ckb deletion evidence_span: {"source_cache": "artifacts/creatine-research/35235777.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958", "start_char": 0, "end_char": 1025, "text_sha256": "a81515a03473f41d52c2e13de56ac9b13ea5cd813e288d166159d517f9855958"} [creatine-p35235777] Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. (2022). https://pubmed.ncbi.nlm.nih.gov/35235777/ DOI: 10.1016/j.celrep.2022.110446
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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