Component

Antitumor T-cell function in mouse models

Antitumor T-cell function in mouse models. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Creatine supplementation suppressed tumor growth in the tested mouse models and enhanced the effects of PD-1/PD-L1 checkpoint blockade.

    Creatine → Antitumor T-cell function in mouse models source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"}
    experimental_model
    Transporter-deficient T cells, tumor models and supplementation experiments
    exposure
    Slc6a8 deletion; creatine administration with or without checkpoint blockade
    limitations
    Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    Creatine helped in these mouse immune experiments; benefit for people with cancer was not established.
    primary_references
    [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    tissue_or_cell_type
    CD8 T cells and transplanted tumor models

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 594–605

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-deficient T cells, tumor models and supplementation experiments · source_derived_draft · unverified_draft

    ### creatine-mouse-tumor-supplement Creatine supplementation suppressed tumor growth in the tested mouse models and enhanced the effects of PD-1/PD-L1 checkpoint blockade. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Creatine helped in these mouse immune experiments; benefit for people with cancer was not established. organism: Mice tissue_or_cell_type: CD8 T cells and transplanted tumor models experimental_model: Transporter-deficient T cells, tumor models and supplementation experiments limitations: Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred. exposure: Slc6a8 deletion; creatine administration with or without checkpoint blockade evidence_span: {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"} [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    Complete structured claim and evidence

  2. Loss of Slc6a8 impaired CD8 T-cell antitumor immunity in the studied mouse models.

    Mouse creatine transporter / Slc6a8 → Antitumor T-cell function in mouse models source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"}
    experimental_model
    Transporter-deficient T cells, tumor models and supplementation experiments
    exposure
    Slc6a8 deletion; creatine administration with or without checkpoint blockade
    limitations
    Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Mice
    plain_language
    Having creatine available outside cells did not replace the missing transporter.
    primary_references
    [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    tissue_or_cell_type
    CD8 T cells and transplanted tumor models
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 581–592

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter-deficient T cells, tumor models and supplementation experiments · source_derived_draft · unverified_draft

    ### creatine-tumor-transporter-loss Loss of Slc6a8 impaired CD8 T-cell antitumor immunity in the studied mouse models. Condition category: machinery_impairment nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Having creatine available outside cells did not replace the missing transporter. organism: Mice tissue_or_cell_type: CD8 T cells and transplanted tumor models experimental_model: Transporter-deficient T cells, tumor models and supplementation experiments limitations: Preclinical tumor immunity; no human cancer efficacy or universal tumor effect is inferred. exposure: Slc6a8 deletion; creatine administration with or without checkpoint blockade evidence_span: {"source_cache": "artifacts/creatine-research/31628186.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458", "start_char": 0, "end_char": 1076, "text_sha256": "2547f09774244dc13d8bd95950b9b313b7fa625436ab778bb52913a64f2ae458"} [creatine-p31628186] Creatine uptake regulates CD8 T cell antitumor immunity. (2019). https://pubmed.ncbi.nlm.nih.gov/31628186/ DOI: 10.1084/jem.20182044
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards