Component
Mouse dopamine transporter / Slc6a3
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
DAT knockout abolished the usual modafinil wake-promoting response in mice while caffeine remained effective with enhanced response.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
- experimental_condition
- Modafinil in wild-type mice drug challenge · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Modafinil in wild-type mice knockout · Mouse dopamine transporter / Slc6a3 Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Modafinil in DAT-knockout mice", "comparator": "Modafinil in wild-type mice", "endpoint": "DAT knockout abolished the usual modafinil wake-promoting response in mice while caffeine remained effective with enhanced response.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "mouse-slc6a3", "state": "knockout"}, {"entity_slug": "modafinil", "state": "drug challenge"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Constitutive mouse DAT knockout; baseline and developmental compensation constrain interpretation.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- DAT knockout abolished the usual modafinil wake-promoting response in mice while caffeine remained effective with enhanced response.
- primary_references
- Dopaminergic role in stimulant-induced wakefulness. | 2001 | DOI 10.1523/jneurosci.21-05-01787.2001 | PMID 11222668 | https://pubmed.ncbi.nlm.nih.gov/11222668/
- source_locator
- Reviewed reference lines 50-50; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 50–50
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Constitutive mouse DAT knockout; baseline and developmental compensation constrain interpretation. · Recorded from source · Recorded from source
In DAT-knockout mice, modafinil lost its usual wake-promoting effect; caffeine remained effective and produced an enhanced response. This supports a DAT-dependent route in that model, rather than a general inability of those mice to awaken. Developmental compensation and changed baseline physiology still limit extrapolation from a constitutive knockout. [Wisor et al., 2001](https://pubmed.ncbi.nlm.nih.gov/11222668/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.