Mouse heme transporter HRG1 / Slc48a1: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Hrg1 depletion attenuated heme transport from macrophage phagolysosomes.
Mouse heme transporter HRG1 / Slc48a1 → Heme export from the macrophage phagolysosome source_derived_draftungraded
Experimental context and source evidence
availability_state
machinery_impairment Imported condition classification; unverified.
evidence_span
{"source_cache": "artifacts/iron-research/23395172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b", "start_char": 0, "end_char": 1074, "text_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b"}
experimental_model
Macrophage depletion, localization and human variant assays
exposure
Hrg1 depletion and missense variants
limitations
Recycling pathway experiment; no estimate of dietary iron requirements is derived.
nutrient_topic
Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
organism
Mouse macrophages and human HRG1 variants
plain_language
A blocked recycling step can trap useful material inside a cellular compartment.
primary_references
[iron-p23395172] HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. (2013). https://pubmed.ncbi.nlm.nih.gov/23395172/ DOI: 10.1016/j.cmet.2013.01.005
tissue_or_cell_type
Phagolysosomes during erythrophagocytosis
trigger_kind
machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 563–574
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Macrophage depletion, localization and human variant assays · source_derived_draft · unverified_draft
### iron-hrg1-loss Hrg1 depletion attenuated heme transport from macrophage phagolysosomes. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A blocked recycling step can trap useful material inside a cellular compartment. organism: Mouse macrophages and human HRG1 variants tissue_or_cell_type: Phagolysosomes during erythrophagocytosis experimental_model: Macrophage depletion, localization and human variant assays limitations: Recycling pathway experiment; no estimate of dietary iron requirements is derived. exposure: Hrg1 depletion and missense variants evidence_span: {"source_cache": "artifacts/iron-research/23395172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b", "start_char": 0, "end_char": 1074, "text_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b"} [iron-p23395172] HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. (2013). https://pubmed.ncbi.nlm.nih.gov/23395172/ DOI: 10.1016/j.cmet.2013.01.005
Complete structured claim and evidence
Hrg1 localized to phagolysosomal membranes during erythrophagocytosis and transported heme toward the macrophage cytoplasm.
Mouse heme transporter HRG1 / Slc48a1 → Heme export from the macrophage phagolysosome source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/iron-research/23395172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b", "start_char": 0, "end_char": 1074, "text_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b"}
experimental_model
Macrophage depletion, localization and human variant assays
exposure
Hrg1 depletion and missense variants
limitations
Recycling pathway experiment; no estimate of dietary iron requirements is derived.
nutrient_topic
Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
organism
Mouse macrophages and human HRG1 variants
plain_language
Macrophages must move heme out of the compartment where old red cells are broken down.
primary_references
[iron-p23395172] HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. (2013). https://pubmed.ncbi.nlm.nih.gov/23395172/ DOI: 10.1016/j.cmet.2013.01.005
tissue_or_cell_type
Phagolysosomes during erythrophagocytosis
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 550–561
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Macrophage depletion, localization and human variant assays · source_derived_draft · unverified_draft
### iron-hrg1-recycling Hrg1 localized to phagolysosomal membranes during erythrophagocytosis and transported heme toward the macrophage cytoplasm. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Macrophages must move heme out of the compartment where old red cells are broken down. organism: Mouse macrophages and human HRG1 variants tissue_or_cell_type: Phagolysosomes during erythrophagocytosis experimental_model: Macrophage depletion, localization and human variant assays limitations: Recycling pathway experiment; no estimate of dietary iron requirements is derived. exposure: Hrg1 depletion and missense variants evidence_span: {"source_cache": "artifacts/iron-research/23395172.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b", "start_char": 0, "end_char": 1074, "text_sha256": "9ffc7159cfb418fed987d6f3f9e34829861a8f4ede0fe564a2714ef0bc96968b"} [iron-p23395172] HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. (2013). https://pubmed.ncbi.nlm.nih.gov/23395172/ DOI: 10.1016/j.cmet.2013.01.005
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Mouse heme transporter HRG1 / Slc48a1