Component
Mouse Slc39a4 messenger RNA
Transcript encoding mouse ZIP4; zinc-dependent stability is distinct from transcription.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Dietary zinc deficiency increased mouse Zip4 mRNA by greater transcript stability rather than an increased relative transcription rate.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Mouse intestine with nuclear run-on assays; supporting Hepa-cell analyses
- exposure
- Defined zinc-deficient versus adequate diets; transcription assessed after 24 hours from gestational day 8.
- limitations
- Transcript stabilization in mice is not a serum-zinc threshold or proof that all zinc deficiency responses are post-transcriptional.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Mus musculus
- plain_language
- With little dietary zinc, mice preserve the message used to make ZIP4.
- primary_references
- [zinc-trans-18020946] Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). (2007). https://pubmed.ncbi.nlm.nih.gov/18020946/ DOI: 10.1515/bc.2007.149
- tissue_or_cell_type
- Small intestine; supporting cultured hepatic cells
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 232–243
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse intestine with nuclear run-on assays; supporting Hepa-cell analyses · source_derived_draft · unverified_draft
### zinc-trans-zip4-mrna-stability Dietary zinc deficiency increased mouse Zip4 mRNA by greater transcript stability rather than an increased relative transcription rate. Condition category: nutrient_deficiency nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: With little dietary zinc, mice preserve the message used to make ZIP4. organism: Mus musculus tissue_or_cell_type: Small intestine; supporting cultured hepatic cells experimental_model: Mouse intestine with nuclear run-on assays; supporting Hepa-cell analyses limitations: Transcript stabilization in mice is not a serum-zinc threshold or proof that all zinc deficiency responses are post-transcriptional. exposure: Defined zinc-deficient versus adequate diets; transcription assessed after 24 hours from gestational day 8. cross_nutrient: false [zinc-trans-18020946] Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). (2007). https://pubmed.ncbi.nlm.nih.gov/18020946/ DOI: 10.1515/bc.2007.149
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.