Component

Inducible mouse Slc34a2 knockout in the 2009 absorption study

Inducible mouse Slc34a2 knockout in the 2009 absorption study. Species, exposure and limitations are retained in each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. After low-phosphate feeding and an acute phosphate bolus, Slc34a2-null mice absorbed approximately 50% less phosphate than wild type.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse intestinal phosphate absorption source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    Removing the intestinal transporter reduced absorption under the specified feeding conditions.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 230–241

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-absorption After low-phosphate feeding and an acute phosphate bolus, Slc34a2-null mice absorbed approximately 50% less phosphate than wild type. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Removing the intestinal transporter reduced absorption under the specified feeding conditions. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

  2. Slc34a2-null mice excreted more phosphate in feces.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse fecal phosphate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    More phosphorus left through the gut.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 243–254

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-fecal Slc34a2-null mice excreted more phosphate in feces. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: More phosphorus left through the gut. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

  3. The Slc34a2-null phenotype included reduced circulating FGF23.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse fibroblast growth factor 23 / Fgf23 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    A phosphate-wasting hormone fell as part of the compensatory pattern.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 282–293

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-fgf23 The Slc34a2-null phenotype included reduced circulating FGF23. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: A phosphate-wasting hormone fell as part of the compensatory pattern. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

  4. Renal NaPi-IIa protein expression increased in Slc34a2-null mice.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse sodium-phosphate cotransporter NaPi-IIa / Slc34a1 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    The renal transporter increased while intestinal transport was absent.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 295–306

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-npt2a Renal NaPi-IIa protein expression increased in Slc34a2-null mice. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The renal transporter increased while intestinal transport was absent. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

  5. Serum phosphate remained unchanged in the Slc34a2-null mice despite altered intestinal and urinary handling.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse serum inorganic phosphate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    A normal blood measurement did not mean the transport system was unchanged.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 269–280

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-serum Serum phosphate remained unchanged in the Slc34a2-null mice despite altered intestinal and urinary handling. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: A normal blood measurement did not mean the transport system was unchanged. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

  6. Slc34a2-null mice excreted less phosphate in urine.

    Inducible mouse Slc34a2 knockout in the 2009 absorption study → Mouse urinary phosphate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"}
    experimental_model
    Inducible Slc34a2 knockout, balance measurements and isolated ileum transport
    exposure
    Knockout versus wild type; low-P diet followed by an acute phosphate bolus
    limitations
    Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Mouse
    plain_language
    The kidneys conserved phosphate when gut uptake was impaired.
    primary_references
    [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    tissue_or_cell_type
    Intestine and compensatory renal handling
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 256–267

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Inducible Slc34a2 knockout, balance measurements and isolated ileum transport · source_derived_draft · unverified_draft

    ### phosphorus-npt2b-urine Slc34a2-null mice excreted less phosphate in urine. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The kidneys conserved phosphate when gut uptake was impaired. organism: Mouse tissue_or_cell_type: Intestine and compensatory renal handling experimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport limitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates. exposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus evidence_span: {"source_cache": "artifacts/phosphorus-research/19729436.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d", "start_char": 0, "end_char": 1402, "text_sha256": "db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d"} [phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards