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Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Removing the intestinal transporter reduced absorption under the specified feeding conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. (2009). https://pubmed.ncbi.nlm.nih.gov/19729436/ DOI: 10.1681/asn.2009050559","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine and compensatory renal handling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b0d651a4-2e81-58f6-98ee-e85e8b84fd9e","evidence_kind":"source_excerpt","locator":"Lines 230-241","start_line":230,"end_line":241,"excerpt":"### phosphorus-npt2b-absorption\nAfter low-phosphate feeding and an acute phosphate bolus, Slc34a2-null mice absorbed approximately 50% less phosphate than wild type.\nCondition category: machinery_impairment\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Removing the intestinal transporter reduced absorption under the specified feeding conditions.\norganism: Mouse\ntissue_or_cell_type: Intestine and compensatory renal handling\nexperimental_model: Inducible Slc34a2 knockout, balance measurements and isolated ileum transport\nlimitations: Fraction of active transport is not the fraction of total absorption in every diet or species. Normal serum phosphate can coexist with impaired intestinal entry because the kidney compensates.\nexposure: Knockout versus wild type; low-P diet followed by an acute phosphate bolus\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/19729436.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d\", \"start_char\": 0, \"end_char\": 1402, \"text_sha256\": \"db886399fafd3fc4da4c341765ec69ebb7948f4993e271ca6ee6855d8ba7616d\"}\n[phosphorus-p19729436] Intestinal npt2b plays a major role in phosphate absorption and homeostasis. 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