Component
Mouse copper transporter Ctr2 / Slc31a2
Mouse copper transporter Ctr2 / Slc31a2. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Ctr2 was required for normal formation of the ectodomain-cleaved form of Ctr1 in mice.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/24167251.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968", "start_char": 0, "end_char": 1212, "text_sha256": "7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968"}
- experimental_model
- Ctr2 knockout and Ctr1 processing experiments
- exposure
- Ctr2 deletion
- limitations
- CTR2 regulates truncated CTR1 and intracellular mobilization; it should not simply be treated as a duplicate plasma-membrane CTR1 importer.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Mouse
- plain_language
- One copper transporter controls the processing of another.
- primary_references
- [copper-p24167251] Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. (2013). https://pubmed.ncbi.nlm.nih.gov/24167251/ DOI: 10.1073/pnas.1311749110
- tissue_or_cell_type
- Tissues and endosomal copper pools
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 468–479
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ctr2 knockout and Ctr1 processing experiments · source_derived_draft · unverified_draft
### copper-ctr2-ctr1-cleavage Ctr2 was required for normal formation of the ectodomain-cleaved form of Ctr1 in mice. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: One copper transporter controls the processing of another. organism: Mouse tissue_or_cell_type: Tissues and endosomal copper pools experimental_model: Ctr2 knockout and Ctr1 processing experiments limitations: CTR2 regulates truncated CTR1 and intracellular mobilization; it should not simply be treated as a duplicate plasma-membrane CTR1 importer. exposure: Ctr2 deletion evidence_span: {"source_cache": "artifacts/copper-research/24167251.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968", "start_char": 0, "end_char": 1212, "text_sha256": "7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968"} [copper-p24167251] Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. (2013). https://pubmed.ncbi.nlm.nih.gov/24167251/ DOI: 10.1073/pnas.1311749110
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.