{"id":"a90612f7-c5de-557a-8f50-e17937ec287c","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-ctr2-ctr1-cleavage","predicate":"supports_formation_of","statement":"Ctr2 was required for normal formation of the ectodomain-cleaved form of Ctr1 in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a8649242-962c-53e4-86c2-75307eaf2c40","mechanism_event_label":"One copper transporter controls the processing of another.","subject":{"id":"2e288380-8396-56b7-a675-8ec464adddc4","slug":"mouse-slc31a2","display_name":"Mouse copper transporter Ctr2 / Slc31a2","entity_type_key":"protein"},"object":{"id":"89ff6a87-8777-5d3c-99be-68eac76e3e05","slug":"mouse-ctr1-truncated","display_name":"Mouse Ctr1 with cleaved extracellular N-terminal domain","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"a8649242-962c-53e4-86c2-75307eaf2c40","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-ctr2-ctr1-cleavage-event","event_type":"biochemical_relationship","label":"One copper transporter controls the processing of another.","description":"Ctr2 was required for normal formation of the ectodomain-cleaved form of Ctr1 in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2e288380-8396-56b7-a675-8ec464adddc4","slug":"mouse-slc31a2","display_name":"Mouse copper transporter Ctr2 / Slc31a2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89ff6a87-8777-5d3c-99be-68eac76e3e05","slug":"mouse-ctr1-truncated","display_name":"Mouse Ctr1 with cleaved extracellular N-terminal domain","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/24167251.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968\", \"start_char\": 0, \"end_char\": 1212, \"text_sha256\": \"7315e9041dddd5510d6efd970560c80316d38120ba1d8eefca10952be8ea0968\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ctr2 knockout and Ctr1 processing experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ctr2 deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"CTR2 regulates truncated CTR1 and intracellular mobilization; it should not simply be treated as a duplicate plasma-membrane CTR1 importer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One copper transporter controls the processing of another.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p24167251] Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. 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