Component
Mouse glucose transporter GLUT1 / Slc2a1
Mouse glucose transporter GLUT1 / Slc2a1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Berberine acutely increased GLUT1-mediated uptake in L929 cells and decreased apparent glucose-uptake Km without changing Vmax.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/21545824.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "18e315a501ae688fc71a7761667e58ae71fdd4b3fae19b7ef0f83889dbae2825", "start_char": 0, "end_char": 1865, "text_sha256": "18e315a501ae688fc71a7761667e58ae71fdd4b3fae19b7ef0f83889dbae2825"}
- experimental_model
- Acute glucose-uptake kinetics and kinase inhibitors
- exposure
- Minutes of berberine exposure; maximum stimulation above 40 micromolar
- limitations
- Single-cell model and high concentrations; kinase inhibitors are not fully selective. No inference of a matching human glucose-lowering magnitude.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Mouse L929 fibroblasts expressing GLUT1
- plain_language
- A transporter can move glucose differently without the cell making more transporters.
- primary_references
- [berberine-p21545824] Berberine acutely activates the glucose transport activity of GLUT1. (2011). https://pubmed.ncbi.nlm.nih.gov/21545824/ DOI: 10.1016/j.biochi.2011.04.013
- tissue_or_cell_type
- GLUT1-mediated glucose uptake
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 519–530
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Acute glucose-uptake kinetics and kinase inhibitors · source_derived_draft · unverified_draft
### berberine-glut1-activation Berberine acutely increased GLUT1-mediated uptake in L929 cells and decreased apparent glucose-uptake Km without changing Vmax. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter can move glucose differently without the cell making more transporters. organism: Mouse L929 fibroblasts expressing GLUT1 tissue_or_cell_type: GLUT1-mediated glucose uptake experimental_model: Acute glucose-uptake kinetics and kinase inhibitors limitations: Single-cell model and high concentrations; kinase inhibitors are not fully selective. No inference of a matching human glucose-lowering magnitude. exposure: Minutes of berberine exposure; maximum stimulation above 40 micromolar evidence_span: {"source_cache": "artifacts/berberine-research/21545824.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "18e315a501ae688fc71a7761667e58ae71fdd4b3fae19b7ef0f83889dbae2825", "start_char": 0, "end_char": 1865, "text_sha256": "18e315a501ae688fc71a7761667e58ae71fdd4b3fae19b7ef0f83889dbae2825"} [berberine-p21545824] Berberine acutely activates the glucose transport activity of GLUT1. (2011). https://pubmed.ncbi.nlm.nih.gov/21545824/ DOI: 10.1016/j.biochi.2011.04.013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.