Component
SAC-associated protection in mouse cerebral ischemia
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Nrf2 knockout mice did not show the ischemic protection observed with systemic SAC in wild-type mice.
Experimental context and source evidence
- acting_entity
- mouse-nfe2l2
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Not specified in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary abstract
- experimental_comparison
- SAC versus ischemic control; wild-type versus Nrf2 knockout
- experimental_model
- Middle cerebral artery occlusion in wild-type and Nrf2 knockout mice
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- Necessity in this model; not proof that every SAC effect requires Nrf2.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Mus musculus
- plain_language
- Removing the pathway changed the response to SAC.
- primary_references
- [25393425] S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25393425/ · DOI 10.1111/jnc.12986
- route
- Systemic administration; precise route not retrieved
- tissue_or_cell_type
- Middle cerebral artery occlusion in wild-type and Nrf2 knockout mice
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 140–147
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Middle cerebral artery occlusion in wild-type and Nrf2 knockout mice · source_derived_draft · unverified_draft
## s-allylcysteine-mouse-nrf2-required Removing the pathway changed the response to SAC. Nrf2 knockout mice did not show the ischemic protection observed with systemic SAC in wild-type mice. Model: Middle cerebral artery occlusion in wild-type and Nrf2 knockout mice Limitations: Necessity in this model; not proof that every SAC effect requires Nrf2. Evidence access: Primary abstract [25393425] S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25393425/ · DOI 10.1111/jnc.12986 Structured context: {"organism": "Mus musculus", "tissue_or_cell_type": "Middle cerebral artery occlusion in wild-type and Nrf2 knockout mice", "dose": "Not specified in accessed abstract", "duration": "Not specified in accessed abstract", "route": "Systemic administration; precise route not retrieved", "experimental_comparison": "SAC versus ischemic control; wild-type versus Nrf2 knockout", "acting_entity": "mouse-nfe2l2", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.